Actively Recruiting
Skin Cancer and Hyperthermia and Radiotherapy
Led by Kantonsspital Winterthur KSW · Updated on 2025-06-15
100
Participants Needed
4
Research Sites
182 weeks
Total Duration
On this page
Sponsors
K
Kantonsspital Winterthur KSW
Lead Sponsor
L
Luzerner Kantonsspital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The SAHARA trial assesses wether combining ultrahypofractionated accelerated radiotherapy (RT) with hyperthermia is as effective as standard hypofractionated high-dose radiation in treating non-melanoma skin cancer (NMSC).
CONDITIONS
Official Title
Skin Cancer and Hyperthermia and Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent
- Histologically confirmed invasive non-melanoma skin cancer (basal cell carcinoma or squamous cell carcinoma)
- Tumor stage T2 or higher (TNM Classification 8th Edition)
- Tumor thickness up to 2 cm (based on pathology or imaging)
- Local recurrence allowed if primary treatment was more than 6 months ago (excluding prior radiotherapy)
- Age 65 years or older
- ECOG performance status 0 to 2 with life expectancy over 6 months
- Presentation at Swiss Hyperthermia Network tumor conference required
You will not qualify if you...
- Any cancer histology other than basal cell carcinoma or squamous cell carcinoma
- Tumor stage T1 or presence of lymph node involvement (N+)
- Tumors after incomplete resection (R1 or R2) or requiring adjuvant treatment
- Tumor invading critical areas
- Multiple lesions exceeding one treatment/radiation field capacity
- Chemotherapy or immunotherapy within one month prior or ongoing
- Connective tissue disorders such as scleroderma or lupus erythematosus
- Lesions inside or within 3 cm of previously irradiated areas
- Medical immunosuppression
- Tattoos in irradiated area
- Increased photosensitivity due to medications or conditions like porphyria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Kantonsspital Aarau
Aarau, Canton of Aargau, Switzerland, 5001
Actively Recruiting
2
Kantonsspital Winterthur
Winterthur, Canton of Zurich, Switzerland, 8401
Actively Recruiting
3
Lindenhofgruppe
Bern, Switzerland, 3001
Actively Recruiting
4
Luzerner Kantonsspital
Lucerne, Switzerland, 6000
Actively Recruiting
Research Team
N
Nidar Batifi, MSc
CONTACT
D
Daniel Zwahlen, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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