Actively Recruiting
Skin Microbial Ecology in Atopic Dermatitis
Led by University of Rochester · Updated on 2025-06-05
240
Participants Needed
1
Research Sites
415 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Everybody's skin has bacteria that normally lives on it. Previous research has shown that people with eczema (or atopic dermatitis \[AD\]) have much higher concentrations of a certain bacteria (S. aureus), especially when their disease is active but little is known about the role that this bacteria plays in psoriasis (i.e. disease severity, biomarkers and skin barrier function). The overarching purpose of this longitudinal study is to understand how the abundance of skin S. aureus (and several commensal bacteria) change as a consequence of standard of care treatment in the URMC dermatology clinics. Other assays and biospecimens will also be collected to address a number of questions.
CONDITIONS
Official Title
Skin Microbial Ecology in Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 13 to 65 years (inclusive) for psoriasis; aged 13 years or older for atopic dermatitis and healthy controls
- Optional skin biopsy substudy limited to adults aged 18 to 65 years
- Able to understand the study and give consent
- Able to attend clinic visits and follow study procedures
- Able to read, speak, and understand English
- Chronic atopic dermatitis diagnosed by American Academy of Dermatology criteria present for at least 1 year
- Chronic psoriasis diagnosed by American Academy of Dermatology criteria present for at least 1 year
- Atopic dermatitis subjects have active lesions on upper extremities, lower extremities, or trunk with moderate to severe disease (EASI ≥12)
- Psoriasis subjects have active lesions on upper extremities, lower extremities, or trunk with moderate to severe disease (PASI ≥7)
You will not qualify if you...
- Unable or unwilling to complete informed consent
- Age under 13 or over 65 years for psoriasis; under 13 years for atopic dermatitis and healthy controls
- Atopic dermatitis subjects without lesions on upper extremities, lower extremities, or trunk
- Atopic dermatitis subjects with disease severity less than moderate (EASI <12)
- Psoriasis subjects without lesions on upper extremities, lower extremities, or trunk
- Psoriasis subjects with disease severity less than moderate (PASI <7)
- Healthy controls diagnosed with any inflammatory skin disease
- Severe other illnesses that could affect study participation (e.g., HIV, autoimmune diseases, severe heart failure, history of cancer except certain skin or cervical cancers)
- Recent bacterial, fungal, or viral infection treated with systemic therapy within the last month
- History of serious allergic reactions to tape or adhesives (may participate but cannot undergo tape stripping)
- For biopsy substudy: history of keloid formation or allergy to lidocaine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester Medical Center
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
D
Dermatology clinical trials unit
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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