Actively Recruiting
Skin Preparation for Elective Foot and Ankle Surgery
Led by University of Missouri-Columbia · Updated on 2026-04-27
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Surgical site infections are a common problem in hospitals, especially after foot and ankle surgeries, where infection rates range from 0.4% to 3.6%. This research aims to evaluate whether adding a "pre-scrub" with isopropyl alcohol and chlorhexidine soap before the usual skin preparation can reduce microbial presence and surgical site infections. The study is a Phase 4 randomized trial sponsored by the University of Missouri-Columbia. Participants will be randomly assigned to one of two groups. The control group will have the standard skin preparation using iodine or chlorhexidine solution before surgery. The experimental group will receive this usual preparation plus an additional two-minute scrub of the limb with chlorhexidine soap and isopropyl alcohol applied and allowed to dry before sterile draping. During the study, participants will be monitored for 90 days after surgery to track surgical site infections and microbial load on the skin. Researchers will collect data on infection rates and bacterial presence to assess the effectiveness of the additional pre-scrub. This study includes adult patients undergoing elective foot and ankle surgeries, with follow-up visits or assessments scheduled as needed for safety and outcome measurements.
CONDITIONS
Brief Title
Skin Preparation for Elective Foot and Ankle Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing elective foot and ankle surgeries
- Age over 18 years
You will not qualify if you...
- Surgery due to trauma
- Open injuries
- Non-elective procedures
- Amputations
- Prior surgical site infection through the planned incision
- Pregnancy; participants of child-bearing potential must follow standard pre-operative pregnancy testing protocols
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to day of surgery
Participants receive skin preparation with either iodine or chlorhexidine solution prior to surgery, with some also receiving an additional pre-scrub with isopropyl alcohol and chlorhexidine soap.
1 visit on the day of surgery (in-person)
Duration - 90 days
Participants are monitored for surgical site infection and microbial load after surgery.
Follow-up visits as per standard post-operative care
Trial Site Locations
Total: 1 location
1
University of Missouri
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
V
Vicki L Jones, MEd, CCRP
K
Kyle Schweser, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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