Actively Recruiting
Skin Wetting in Burn Survivors to Reduce Body Temperature During Exercise in Hot Conditions
Led by University of Texas Southwestern Medical Center · Updated on 2025-10-21
40
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of whole body skin wetting to reduce excessive increases in internal body temperature during physical activity in well-healed burn survivors. The study includes non-burned control subjects and burn survivors with burns covering approximately 20% to over 40% of their body surface area. Participants will exercise in hot, dry conditions with either no cooling or whole body skin wetting to compare effects. Participants will be randomly assigned to exercise for 60 minutes in a hot and dry environment under two conditions: one without any cooling and one with whole body skin wetting applied by spraying water over the entire body during exercise. The study uses a crossover design so that each participant experiences both conditions. During the study, researchers will monitor core temperature, mean skin temperature, rate pressure product, and whole body sweat rate before and throughout exercise sessions. Assessments will occur over about 90 minutes, including measurements before, during, and after exercise. The study aims to understand how skin wetting affects body temperature regulation and cardiovascular response during physical activity in burn survivors and controls. The trial is expected to continue until July 2026.
CONDITIONS
Brief Title
Skin Wetting in Burn Survivors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy male and female subjects
- Age between 18 and 65 years
- Free of any underlying medical conditions
- For burn survivors: burn injury covering 20-40% or more than 40% of body surface area with at least 50% full thickness burns requiring skin grafting
- For burn survivors: hospitalization for burn injury for at least 15 days
You will not qualify if you...
- Burn-related injuries requiring at least one night of hospitalization (for non-burned individuals)
- Heart disease or other chronic medical conditions needing regular therapy including cancer, diabetes, hypertension
- Abnormalities detected on routine screening
- Participation in structured moderate to high intensity aerobic exercise training
- Current smokers or those who smoked regularly within the past 3 years
- Body mass index over 30 kg/m2
- Pregnant individuals
- Extensive unhealed injured skin (for burn survivors only)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 90 minutes per exercise session
Participants exercise for 60 minutes in a hot and dry environment with either whole body skin wetting or no cooling. These interventions are performed in a randomized crossover design.
2 exercise visits (in-person), one for each intervention
Trial Site Locations
Total: 1 location
1
Institute for Exercise and Environmental Medicine
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
C
Craig Crandall, PhD
E
Erin Harper, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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