Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women.
Kristine Yaffe, Alison M Laffan, Stephanie Litwack Harrison...
https://pubmed.ncbi.nlm.nih.gov/21828324Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID06089096
Exploring the Association of Sleep Apnea With Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Led by The University of Hong Kong · Updated on 2025-04-02
250
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on obstructive sleep apnea (OSA), a condition where the airway becomes partially or fully blocked during sleep, causing intermittent drops in oxygen and disrupted sleep. OSA has been linked to higher risks of cognitive problems like mild cognitive impairment (MCI) and Alzheimer's disease. The study aims to explore how sleep apnea and related sleep issues relate to cognitive function in people reporting cognitive difficulties, contributing to future research in this area. Participants will undergo cognitive testing, complete questionnaires, and receive a Home Sleep Apnea Test (HSAT) at the start of the study. This observational study examines sleep study parameters and various symptoms, including daytime sleepiness, insomnia, depression, and daily living activities, alongside cognitive function and the ability to manage cognitive interference. During the study, researchers will assess sleep quality, apnea symptoms, and neurocognitive status using baseline tests and questionnaires. The study also includes monitoring of mood and daily functioning. Participants' involvement centers on providing data through tests and self-reports, with no active treatment given. The study is led by The University of Hong Kong and started in March 2023, continuing to March 2027.
CONDITIONS
Brief Title
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Aged 18 years and above
- Clinical diagnosis of mild cognitive impairment based on Petersen's criteria or diagnosis of subjective cognitive impairment
- Able to speak and read Chinese
- Adequate vision and hearing to perform cognitive tests
You will not qualify if you...
- Diagnosed psychiatric illness with or without medication, such as major depressive disorder
- Other clear organic causes of cognitive impairment, including old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance or alcohol abuse
- Diagnosis of major unstable illness or cancer undergoing active treatment
- Unable to perform the Home Sleep Apnea Test
- Patients who require legal guardians
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline
Participants complete cognitive tests, questionnaires, and a Home Sleep Apnea Test to assess sleep apnea and cognitive function.
1 visit (at baseline)
Trial Site Locations
Total: 1 location
1
Queen Mary Hospital
Hong Kong, Hong Kong
Actively Recruiting
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Research Team
S
Sau Man Mary Ip, MD
Y
Yuen Kwan Agnes Lai, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
The Association Between Obstructive Sleep Apnea and Alzheimer's Disease: A Meta-Analysis Perspective.
Farnoosh Emamian, Habibolah Khazaie, Masoud Tahmasian...
https://pubmed.ncbi.nlm.nih.gov/27148046Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis.
Yue Leng, Claire T McEvoy, Isabel E Allen...
https://pubmed.ncbi.nlm.nih.gov/28846764Targeting Sleep and Circadian Function in the Prevention of Alzheimer Disease.
Erik S Musiek, Yo-El S Ju
https://pubmed.ncbi.nlm.nih.gov/35816332