Actively Recruiting
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Led by The University of Hong Kong · Updated on 2025-04-02
250
Participants Needed
1
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive sequelae. Chronic intermittent hypoxia, sleep fragmentation of OSA, and insufficient sleep have been significantly associated with higher risks of neurocognitive impairment, including mild cognitive impairment (MCI) and Alzheimer's disease. Thus, sleep and circadian function might be modifiable neurocognitive impairment factors. The significance of the study is to understand the relationships of MCI with sleep apnea and sleep-related symptoms, which helps pave the groundwork for further research.
CONDITIONS
Official Title
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years and above
- Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria, including memory problems, objective memory disorder, absence of other cognitive disorders or daily life effects, normal general cognitive function, and no dementia OR
- Diagnosis of subjective cognitive impairment based on the participant's own complaint but with normal scores on the Hong Kong version of Montreal Cognitive Assessment
- Able to speak and read Chinese
- Adequate vision and hearing to perform cognitive tests
You will not qualify if you...
- Diagnosed psychiatric illness with or without medication, such as major depressive disorder
- Clear organic causes of cognitive impairment, including old stroke, brain tumor, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, or history of alcohol abuse
- Diagnosis of major unstable illness or cancer currently under active treatment
- Unable to perform Home Sleep Apnea Test
- Patients who require legal guardians
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Queen Mary Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
S
Sau Man Mary Ip, MD
CONTACT
Y
Yuen Kwan Agnes Lai, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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