Actively Recruiting
Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
Led by The Cleveland Clinic · Updated on 2026-04-13
20
Participants Needed
2
Research Sites
70 weeks
Total Duration
On this page
Sponsors
T
The Cleveland Clinic
Lead Sponsor
U
University of Washington
Collaborating Sponsor
AI-Summary
What this Trial Is About
A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).
CONDITIONS
Official Title
Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided informed consent
- Age between 18 and 85 years
- Diagnosed with high burden paroxysmal atrial fibrillation (1% or more)
- Diagnosed with moderate to severe obstructive sleep apnea (apnea-hypopnea index 15 or higher)
- Have an implanted device with atrial diagnostics
- Enrolled in remote monitoring program
You will not qualify if you...
- Had atrial fibrillation ablation within the past 6 months
- Have valvular heart abnormalities
- Experience excessive daytime sleepiness while working in safety-critical jobs
- Planning to undergo ablation during the study
- Receiving sleep apnea treatment other than CPAP
- Had a device implanted within the past 6 months
- Diagnosed with central sleep apnea
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
2
University of Washington
Seattle, Washington, United States, 98195
Not Yet Recruiting
Research Team
M
Mina Chung, MD
CONTACT
R
Reena Mehra, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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