Actively Recruiting
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Led by Massachusetts General Hospital · Updated on 2026-02-11
150
Participants Needed
1
Research Sites
211 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circadian biomarker and post-operative delirium (POD) risk. 3. To determine whether sleep/circadian regulation interacts with the genetic risk of AD to influence POD/cognitive decline. Participants will be asked to: 1. Donate several blood samples both intraoperatively and postoperatively 2. Complete baseline and postoperative neurocognitive assessments 3. Wear an actigraphy data collection watch for the two weeks prior to their surgery
CONDITIONS
Official Title
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3A 70 years old
- Scheduled to undergo major orthopedic surgery
- Expected postoperative recovery of more than 24 hours as an inpatient
You will not qualify if you...
- Cognitive impairment leading to inability to consent
- Limited mobility or inability to wear an actigraphy watch
- Infection at the site of actigraphy watch or allergies to watch materials
- More than two days in the ICU during the month prior to surgery
- Renal or liver failure
- Severe neurocognitive damage or history of psychiatric illness
- Blindness or deafness
- Non-English speaking patients
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
L
Lei Gao, MBBS
CONTACT
E
Elizabeth Gleeson, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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