Actively Recruiting
Sleep Disordered Breathing With Opioid Use
Led by VA Office of Research and Development · Updated on 2025-07-18
150
Participants Needed
1
Research Sites
412 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
J
John D. Dingell VA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use via different mechanisms. We will study additional clinical parameters like quality of life, sleep and pain in patients with and without opioid use. This proposal will enhance the investigators' understanding of the pathways that contribute to the development of sleep apnea with opioid use. The investigators expect that the results obtained from this study will positively impact the health of Veterans by identifying new treatment modalities for sleep apnea.
CONDITIONS
Official Title
Sleep Disordered Breathing With Opioid Use
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans aged 18 to 89 years
- Veterans currently using prescription opioids
You will not qualify if you...
- Body mass index (BMI) over 40 kg/m2
- History of unresolved or untreated cardiac disease, including recent heart attack, recent bypass surgery, and untreated atrial or ventricular tachy-bradycardias
- Congestive heart failure with Cheyne-Stokes respiration
- Current unstable angina
- Recent stroke
- Untreated schizophrenia
- Untreated hypothyroidism
- Unresolved seizure disorder
- Severe respiratory, neurological, liver, or kidney diseases
- Unstable psychiatric disorders or untreated PTSD
- Traumatic brain injury
- Pregnancy
- Significant sleep disorders such as narcolepsy or parasomnias
- Failure to give informed consent
- Current use of tramadol or suboxone/buprenorphine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201-1916
Actively Recruiting
Research Team
R
Ruchi Rastogi, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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