Actively Recruiting
Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
Led by University of California, San Diego · Updated on 2026-02-27
120
Participants Needed
1
Research Sites
207 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of melatonin levels on mood, sleep, and activity. Participants will 1) submit urine samples to measure melatonin levels, 2) be assigned to advance or delay their sleep for one night, 3) sit in front of a light box for 30 minutes per day (morning or evening) for 14 days, 4) complete questionnaires about their mood and sleep, and 5) wear a device that will measure their activity.
CONDITIONS
Official Title
Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Perimenopausal women with irregular menstrual cycles for at least 3 months
- Age 18 years or older
- Experiencing at least moderate depression symptoms (score of at least 10 on PHQ-9)
You will not qualify if you...
- Actively suicidal or psychotic
- History of bipolar disorder
- Recently started medications affecting outcome measures (e.g., melatonin)
- Those for whom sleep restriction is unsafe (e.g., epilepsy or safety-sensitive occupations)
- Women with body mass index (BMI) less than 18 or greater than 30 according to NIH criteria
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of California San Diego Hillcrest Medical Center
San Diego, California, United States, 92103
Actively Recruiting
Research Team
J
Jennifer A Perrott, MSW
CONTACT
D
David Sommerfeld, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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