Actively Recruiting
Sleep Modulation to Treat Depression
Led by Christoph Nissen · Updated on 2024-07-23
60
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Current first-line treatments for major depression (antidepressants and psychotherapy) show a long latency to response, and less than half of all patients experience full remission with optimized treatment, indicating the need for new developments. The aim of this study is to extend and further develop a longstanding line of research of using sleep neurophysiology as a 'window to the brain' and treatment development in major depression. Particularly, this project is designed to test the feasibility, efficacy and mechanisms of action of a new sleep-based treatment technology.
CONDITIONS
Official Title
Sleep Modulation to Treat Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Diagnosis of major depressive disorder according to ICD-10 criteria (F32.1/2, F33.1/2) for the patient group
You will not qualify if you...
- Other relevant psychiatric disorders besides major depressive disorder, including organic psychiatric disorders, substance dependency or abuse (except smoking), schizophrenia, bipolar disorder, borderline personality disorder, autism, or other severe psychiatric disorders
- Known pregnancy
- Unstable medical conditions such as unstable cardiovascular or metabolic disorders
- Relevant neurological disorders including epilepsy and stroke
- Organic sleep disorders including significant sleep apnea, periodic limb movement disorder, restless legs syndrome, narcolepsy, circadian rhythm disorder, or shift work/jet lag
- Use of medications affecting the central nervous system other than antidepressants and lithium; benzodiazepines or (es)ketamine use excluded
- Current brain stimulation treatments such as electroconvulsive therapy, transcranial magnetic stimulation, or deep brain stimulation
- Contraindications for tDCS or TMS studies, including metal in the head/brain or epilepsy
- Hearing impairment or tinnitus
- Inability to follow study procedures (e.g., due to language barriers)
- Left-handedness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Geneva
Geneva, Switzerland
Actively Recruiting
Research Team
C
Christoph Nissen, Prof. Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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