Actively Recruiting

Phase Not Applicable
Age: 6Years - 13Years
All Genders
NCT03865771

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Led by University Hospital, Strasbourg, France · Updated on 2025-12-05

95

Participants Needed

2

Research Sites

440 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture

CONDITIONS

Official Title

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Who Can Participate

Age: 6Years - 13Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Normal psychomotor development
  • Informed consent signed by both parents and subject if able
  • Affiliated to social security regimen
  • Diagnosis of focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
  • Children hospitalized for their follow-up
  • Normal neuroimaging
  • Control group: children hospitalized for a non neurologic disease
Not Eligible

You will not qualify if you...

  • Psychiatric trouble (DSM V)
  • Sensorial trouble without correction
  • Poor command of French language
  • Minor under care
  • Degenerative disease
  • Abnormal neuroimaging
  • Mental deficiency
  • Control group: neurologic trouble
  • Control group: abnormal sleep EEG
  • Control group: intellectual deficiency

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Hopital D'Enfants Pediatrie Medicale Ambulatoire

Nancy, France, 54511

Actively Recruiting

2

Hopital de Hautepierre-Service de Pediatrie/Neurologie

Strasbourg, France, 67098

Actively Recruiting

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Research Team

A

Anne DE SAINT MARTIN, MD

CONTACT

L

Lucille SCHNEIDER

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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