Actively Recruiting
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
Led by University Hospital, Strasbourg, France · Updated on 2025-12-05
95
Participants Needed
2
Research Sites
440 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
CONDITIONS
Official Title
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Normal psychomotor development
- Informed consent signed by both parents and subject if able
- Affiliated to social security regimen
- Diagnosis of focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- Children hospitalized for their follow-up
- Normal neuroimaging
- Control group: children hospitalized for a non neurologic disease
You will not qualify if you...
- Psychiatric trouble (DSM V)
- Sensorial trouble without correction
- Poor command of French language
- Minor under care
- Degenerative disease
- Abnormal neuroimaging
- Mental deficiency
- Control group: neurologic trouble
- Control group: abnormal sleep EEG
- Control group: intellectual deficiency
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Hopital D'Enfants Pediatrie Medicale Ambulatoire
Nancy, France, 54511
Actively Recruiting
2
Hopital de Hautepierre-Service de Pediatrie/Neurologie
Strasbourg, France, 67098
Actively Recruiting
Research Team
A
Anne DE SAINT MARTIN, MD
CONTACT
L
Lucille SCHNEIDER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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