Sleep-specific Deep Brain Stimulation Therapy in Parkinsons Disease Effects on Sleep-wake Disturbances and Neural Activity At University of Minnesota

What this Trial Is About

Sleep-wake disturbances significantly reduce quality of life in people with Parkinsons disease PD, a common progressive neurological disorder. This research aims to better understand the brain circuits involved in these sleep problems and how deep brain stimulation DBS therapy affects sleep-related brain activity and behavior. The study will help guide new treatments for sleep disorders in neurodegenerative diseases like PD. The study involves participants who already have or will receive DBS systems implanted in specific brain areas called the internal segment of the globus pallidus GPi or the subthalamic nucleus STN. These DBS systems deliver electrical stimulation to improve PD motor symptoms. Two separate studies are included Aims 1 2 recruit patients undergoing DBS surgery with research recordings during lead implantation and two nights of sleep monitoring with DBS ON and OFF. Aim 3 recruits patients with bilateral DBS who wear actigraphy watches to monitor sleep before and after clinical programming at 6 and 12 months. Participants will undergo detailed brain imaging, clinical motor exams, and sleep questionnaires. Sleep studies include video-polysomnography and recordings from brain surface strips and DBS leads. Data will be collected during controlled DBS stimulation and analyzed to compare brain activity across sleep stages and DBS settings. Follow-up includes clinical rating scales and actigraphy data at multiple timepoints up to 12 months. The study monitors safety and uses advanced statistical methods to understand DBS effects on sleep in PD.

Sleep-specific DBS Therapy in Parkinson's Disease