Actively Recruiting
Validation and Implementation of Diagnostic Techniques for the Detection of Circulating Factors in Patients With Autoimmune Podocytopathy
Led by Meyer Children's Hospital IRCCS · Updated on 2026-04-08
50
Participants Needed
14
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Nephrotic syndrome is a kidney disorder mainly affecting children, characterized by high protein levels in urine, low protein levels in blood, and swelling. Many children respond to steroid treatment, but some experience relapses, become dependent on therapy, or do not respond to standard treatments, potentially leading to chronic kidney disease. Research suggests that immune system factors, especially autoantibodies against nephrin, a key kidney protein, may influence disease activity and treatment response. This study investigates the presence of anti-nephrin autoantibodies and other autoantibodies targeting kidney filtration components in children and adults with nephrotic syndrome. Researchers will collect and analyze serum and kidney biopsy samples obtained during routine care using advanced laboratory techniques, including ELISA testing and high-resolution microscopy, to better understand these antibodies and their link to kidney structure and function. Participants will provide clinical data and biological samples collected as part of their usual care. The study will analyze anti-nephrin antibody levels from enrollment through five years of follow-up. Data from medical records and laboratory tests will be integrated to explore disease mechanisms and outcomes. This research aims to improve diagnosis and treatment personalization while reducing ineffective therapies.
CONDITIONS
Brief Title
SLIT ABS: Study on Patients With Autoimmune Podocytopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric and adult patients diagnosed with podocytopathy
- Patients with nephrotic syndrome or histological diagnosis of minimal change disease, focal segmental glomerulosclerosis, collapsing glomerulopathy, or diffuse mesangial sclerosis
- Both newly diagnosed and patients already under follow-up at participating centers
- Availability of clinical data from medical records and laboratory reports
- Availability of biological samples such as blood or renal biopsy collected during routine care
- Signed informed consent by patient or legal guardian, with assent when applicable
You will not qualify if you...
- Refusal or inability of the patient, parents, or legal guardian to provide informed consent
- Lack of sufficient clinical data or unavailable biological samples required for the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years
Participants who undergo routine care are observed through analysis of serum and renal biopsy samples collected during routine clinical care for research purposes.
Follow-up visits aligned with routine clinical care for sample collection and data analysis
Trial Site Locations
Total: 14 locations
1
Mayo Clinic
Rochester, Minnesota, United States, 55902
Not Yet Recruiting
2
Ludwig-Maximilians Universitat
München, Germany
Not Yet Recruiting
3
Ospedale Santa Maria Annunziata
Bagno a Ripoli, Firenze, Italy
Not Yet Recruiting
4
Meyer Children's Hospital IRCCS
Florence, FIRENZE, Italy, 50139
Actively Recruiting
5
IRCCS Azienda Ospedaliero - Universitaria
Bologna, Italy
Not Yet Recruiting
6
Azienda Ospedaliero Universitaria Careggi
Florence, Italy
Not Yet Recruiting
7
Ospedale S. Giovanni di Dio
Florence, Italy
Not Yet Recruiting
8
IRCCS Istituto Giannina Gaslini
Genova, Italy
Not Yet Recruiting
9
Azienda Ospedaliero-Universitaria di Parma
Parma, Italy
Not Yet Recruiting
10
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Not Yet Recruiting
11
Ospedale Santo Stefano
Prato, Italy
Not Yet Recruiting
12
Azienda USL - IRCCS
Reggio Emilia, Italy
Not Yet Recruiting
13
Hospital General de México, Mexico City
Mexico City, Mexico
Not Yet Recruiting
14
Bellvitge University Hospital
Barcelona, Spain
Not Yet Recruiting
Research Team
P
Paola Romagnani, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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