Actively Recruiting
Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD
Led by University of Colorado, Denver · Updated on 2024-10-01
120
Participants Needed
1
Research Sites
247 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the effects of exercise rehabilitation on cognition and to evaluate slow wave sleep (SWS) as a biomarker and mediator of response to rehabilitation-induced improvement in cognitive performance among persons with Parkinson's disease (PwP), with the ultimate goal of maximizing rehabilitation efficacy at the individual level (i.e. precision rehabilitation).
CONDITIONS
Official Title
Slow Wave Sleep As a Biomarker of Rehabilitation-induced Cognitive Improvement in PD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of idiopathic Parkinson's disease with bradykinesia plus rest tremor, rigidity, or postural instability
- Hoehn and Yahr stage 2-3 as assessed at screening
- Age 45 years or older
- Stable Parkinson's medications for at least 4 weeks before study start with no expected changes
- Montreal Cognitive Assessment score between 18 and less than 26
- No contraindications to exercise program
You will not qualify if you...
- Failed exercise readiness evaluation at screening
- Regular participation in an exercise program
- Cardiovascular or pulmonary disease including uncontrolled hypertension, congestive heart failure, unstable coronary artery disease, serious arrhythmia, stroke within past year, or chronic obstructive pulmonary disease
- Shift workers
- Signs of atypical Parkinsonism such as cerebellar signs, gaze palsy, apraxia, autonomic failure, or other cortical signs
- Secondary Parkinsonism caused by neuroleptic treatment, multiple strokes, or multiple head injuries
- Inability to walk without assistance
- Deep brain stimulation
- Known narcolepsy
- Untreated sleep apnea
- Any condition that would prevent safe or successful study participation in the investigator's opinion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado, Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
A
Amy W Amara, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here