Slowly Digestible Carbohydrates for GLP-1 Secretion to Study Satiety and Hormone Response in Healthy Adults

What this Trial Is About

Researchers are studying how slowly digestible carbohydrates (SDCs), specifically raw corn starch, affect the hormone glucagon-like peptide-1 (GLP-1) in healthy adults aged 18 to 45. The study aims to find the amount of SDC that increases GLP-1 levels enough to enhance feelings of fullness and reduce hunger, including whether this effect continues after a second meal. The goal is to explore SDC's potential as a food-based agent for weight loss by measuring blood glucose, insulin, and GLP-1 responses. Participants will take part in four study visits spaced at least seven days apart. During each visit, they will consume a randomized test beverage containing either maltodextrin (control) or one of three doses of raw corn starch combined with maltodextrin totaling 75 grams. Blood samples will be collected at seven timepoints over three hours after consumption to measure GLP-1, insulin, and glucose levels. Satiety questionnaires will be completed five times over three hours, followed by a standardized lunch three hours after the test drink. Throughout the study, participants will be closely monitored with multiple blood draws and questionnaires to assess hormone levels and feelings of fullness. The primary outcome is total GLP-1 secretion measured from baseline through 180 minutes post-consumption. Secondary outcomes include satiety scores, blood glucose, and insulin levels. The trial, sponsored by Purdue University, plans to enroll healthy adults and will last until November 2026.

Slowly Digestible Carbohydrates for GLP-1 Secretion