Actively Recruiting

Phase Not Applicable
Age: 18Years - 45Years
All Genders
Healthy Volunteers
NCT07572513

Slowly Digestible Carbohydrates for GLP-1 Secretion

Led by Purdue University · Updated on 2026-05-07

19

Participants Needed

1

Research Sites

29 weeks

Total Duration

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AI-Summary

What this Trial Is About

The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults. In the current study, researchers will observe the amount of SDC that results in clinically meaningful levels of GLP-1, shown by an increase in feelings of fullness and a decrease in hunger, and how long an elevated level of GLP-1 lasts after starch consumption. Researchers aim to address two questions: What amount of SDC maximizes GLP-1-mediated satiety, and does the impact to satiety continue in a second meal? The overall goal is to maximize ileal-digesting SDC's potential use as a food-based agent for weight loss. Researchers will compare 20, 40, and 60 g of raw corn starch compared to a maltodextrin control on total plasma GLP-1 concentrations, insulin, and blood glucose at baseline and 15, 30, 60, 90, 120, and 180 minutes post-consumption of SDC. Researchers will also measure satiety at baseline, 60, 120, 180 minutes and after a second meal. There will be a total of 4 study visits with a least a 7-day break between visits. At each study visit, participants will: * Consume a randomized test beverage (SDC or maltodextrin) * Receive a blood draw at 7 timepoints over 3 hrs * Take a satiety questionnaire 5 times over 3 hrs * Consume a standardized lunch 3 hrs after the test beverage consumption

CONDITIONS

Official Title

Slowly Digestible Carbohydrates for GLP-1 Secretion

Who Can Participate

Age: 18Years - 45Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Healthy adults aged 18 to 45 years
  • Body mass index between 18.5 and 24.9 kg/m2
  • Able to read and speak English
  • Fasting blood glucose levels less than or equal to 100 mg/dL
  • Hemoglobin A1c less than or equal to 5.7%
  • Men or women
Not Eligible

You will not qualify if you...

  • Age below 18 or above 45 years
  • Body mass index below 18.5 or above 24.9 kg/m2
  • Diagnosed with diabetes
  • History of gastrointestinal disease
  • Pregnant or nursing women
  • Use of GLP-1 medications or following weight-loss diets or restrictive eating patterns
  • Dairy or gluten intolerance or allergies

AI-Screening

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Trial Site Locations

Total: 1 location

1

Clinical Research Center at Purdue University

West Lafayette, Indiana, United States, 47907

Actively Recruiting

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Research Team

B

Bruce R Hamaker, Ph.D.

CONTACT

E

Erica de Jong, B.s.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

4

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