Actively Recruiting
Slowly Digestible Carbohydrates for GLP-1 Secretion
Led by Purdue University · Updated on 2026-05-07
19
Participants Needed
1
Research Sites
29 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults. In the current study, researchers will observe the amount of SDC that results in clinically meaningful levels of GLP-1, shown by an increase in feelings of fullness and a decrease in hunger, and how long an elevated level of GLP-1 lasts after starch consumption. Researchers aim to address two questions: What amount of SDC maximizes GLP-1-mediated satiety, and does the impact to satiety continue in a second meal? The overall goal is to maximize ileal-digesting SDC's potential use as a food-based agent for weight loss. Researchers will compare 20, 40, and 60 g of raw corn starch compared to a maltodextrin control on total plasma GLP-1 concentrations, insulin, and blood glucose at baseline and 15, 30, 60, 90, 120, and 180 minutes post-consumption of SDC. Researchers will also measure satiety at baseline, 60, 120, 180 minutes and after a second meal. There will be a total of 4 study visits with a least a 7-day break between visits. At each study visit, participants will: * Consume a randomized test beverage (SDC or maltodextrin) * Receive a blood draw at 7 timepoints over 3 hrs * Take a satiety questionnaire 5 times over 3 hrs * Consume a standardized lunch 3 hrs after the test beverage consumption
CONDITIONS
Official Title
Slowly Digestible Carbohydrates for GLP-1 Secretion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy adults aged 18 to 45 years
- Body mass index between 18.5 and 24.9 kg/m2
- Able to read and speak English
- Fasting blood glucose levels less than or equal to 100 mg/dL
- Hemoglobin A1c less than or equal to 5.7%
- Men or women
You will not qualify if you...
- Age below 18 or above 45 years
- Body mass index below 18.5 or above 24.9 kg/m2
- Diagnosed with diabetes
- History of gastrointestinal disease
- Pregnant or nursing women
- Use of GLP-1 medications or following weight-loss diets or restrictive eating patterns
- Dairy or gluten intolerance or allergies
AI-Screening
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Trial Site Locations
Total: 1 location
1
Clinical Research Center at Purdue University
West Lafayette, Indiana, United States, 47907
Actively Recruiting
Research Team
B
Bruce R Hamaker, Ph.D.
CONTACT
E
Erica de Jong, B.s.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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