Jejuno-Ileal and Jejuno-Colic Diversion as New Bariatric Methods for Treating Diabetes and Obesity: Protocol for a Randomized Clinical Trial

What this Trial Is About

Researchers are evaluating two new surgical methods called jejuno-ileal diversion and jejuno-colic diversion to treat obesity and Type 2 Diabetes. These procedures create a bowel-to-bowel connection allowing food to pass through two routes, aiming to mimic the effects of metabolic surgeries like gastric bypass but with fewer risks such as malnutrition or diarrhea. The study is a prospective randomized clinical trial sponsored by the University of Ostrava to assess the safety and effectiveness of these innovative approaches. The surgeries are performed under general anesthesia using a laparoscopic technique. For jejuno-ileal diversion, an anastomosis is created between the jejunum and ileum using a linear stapler, and for jejuno-colic diversion, the connection is made between the jejunum and transverse colon. After surgery, patients will have follow-up visits scheduled frequently during the first weeks and then up to 36 months to monitor health and surgical outcomes. Participants will attend clinic visits at specific intervals to assess medical history, physical health including weight and body measurements, blood work such as glycated hemoglobin levels, and metabolic studies like mixed meal tolerance tests. Imaging studies will also be done before and after surgery to check the surgical connections. The primary outcomes include weight loss and improvements in diabetes-related markers over 36 months, with safety and quality of life also monitored through questionnaires and clinical exams.

Small Bowel Diversion