Actively Recruiting
Small Doses Muscle Relaxant in General Anesthesia
Led by Mansoura University · Updated on 2024-02-06
60
Participants Needed
1
Research Sites
322 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will be held to assess the effect of minimal dose muscle relaxant on postoperative pulmonary function. The time to extubation in minutes will be the primary outcome as a clinical indicator of the return of muscle power. The extubation time will be defined as the time from injecting the muscle relaxant reversing agent given when regain the train of four (TOF) ratio to 0.9 till removal of endotracheal tube. Intraoperative surgical conditions will be assessed in the form of surgeon satisfaction and the need for more muscle relaxant boluses. Postoperative complications as desaturation (peripheral oxygen saturation (Spo2) less than 90%), the need for re-intubation or ventilation support will be recorded. Patient lung will be assessed using ultrasound-based lung aeration score. Also, the diaphragmatic and intercostal muscle function will be assessed in the early postoperative period. Immediate postoperative pulmonary function tests will be evaluated using simple spirometer. Patients will be followed up for 28 days for detection of pulmonary complications.
CONDITIONS
Official Title
Small Doses Muscle Relaxant in General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged from 20 to 50 years old
- Scheduled for non-cardiothoracic surgery
- Undergoing general anesthesia
- Positioned in supine position during surgery
- Provided informed consent to participate
You will not qualify if you...
- American Society of Anesthesiologists (ASA) score greater than 3
- Suspected full stomach or surgery requiring profound muscle relaxation or dressing that interferes with ultrasound probe positioning
- Presence of lung parenchymal disease
- Kidney (renal) disease
- Liver (hepatic) disease
- Neuromuscular disease
- Electrolyte imbalance
- Taking medications that affect muscle contraction
- Known allergy to any study drug
AI-Screening
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Trial Site Locations
Total: 1 location
1
Mansoura University-Emergency hospital-ICU
Al Mansurah, Egypt
Actively Recruiting
Research Team
M
Maha Ahmed Abo-Zeid, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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