Actively Recruiting
Small Extracellular Vesicles and Insulin Action
Led by Washington University School of Medicine · Updated on 2025-07-17
72
Participants Needed
1
Research Sites
325 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.
CONDITIONS
Official Title
Small Extracellular Vesicles and Insulin Action
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Metabolically healthy lean subjects must have a BMI 2.5 and 4.9 kg/m2
- Subjects with obesity must have a BMI 0.0 and 5.0 kg/m2
- Metabolically healthy lean and people with metabolically healthy obesity must have intrahepatic triglyceride content 5%
- Fasting plasma glucose concentration less than 100 mg/dl
- 2-hour oral glucose tolerance plasma glucose concentration less than 140 mg/dl
- Hemoglobin A1C (HbA1c) 5.6% or less
- HOMA-IR less than 2.5 for metabolically healthy lean and metabolically healthy obesity
- People with metabolically unhealthy obesity must have intrahepatic triglyceride content 5.6% or higher
- People with metabolically unhealthy obesity must have HOMA-IR 2.5 or higher
- People with metabolically unhealthy obesity must have HbA1c between 5.7% and 6.4%, or fasting plasma glucose 100 mg/dl or higher, or 2-hour oral glucose tolerance test plasma glucose concentration 140 mg/dl or higher
You will not qualify if you...
- History of diabetes
- History of liver disease other than nonalcoholic fatty liver disease
- History of other serious diseases
- Consume excessive amounts of alcohol (more than 21 units/week for men and more than 14 units/week for women)
- Take medications that could affect the study outcome measures
- Engage in regular exercise more than 120 minutes per week
- Are pregnant or lactating
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
K
Kyle Timmons
CONTACT
B
Beth Henk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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