Actively Recruiting
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
Led by McMaster University · Updated on 2025-07-06
3000
Participants Needed
10
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
CONDITIONS
Official Title
Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be a household member of a person with laboratory confirmed monkeypox
- Be aged 2 years or older
- Be within 14 days of illness onset in the monkeypox index case
You will not qualify if you...
- Be pregnant
- Be breastfeeding
- Have had a past serious allergic reaction to components of the study vaccines
- Have previously received smallpox vaccination
- Be currently using or planning to use another investigational drug during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Catholic University of Bukavu
Kinshasa, Bukavu, Democratic Republic of the Congo
Actively Recruiting
2
Federal Medical Center
Abuja, Nigeria
Not Yet Recruiting
3
University of Abuja Teaching Hospital
Abuja, Nigeria
Not Yet Recruiting
4
University of Ibadan
Ibadan, Nigeria
Not Yet Recruiting
5
Irrua Specialist Teaching Hospital
Irrua, Nigeria
Not Yet Recruiting
6
Aminu Kano Teaching Hospital
Kano, Nigeria
Not Yet Recruiting
7
Lagos University Teaching Hospital
Lagos, Nigeria
Not Yet Recruiting
8
Niger Delta Teaching Hospital
Okolobiri, Nigeria
Not Yet Recruiting
9
University of Port Harcourt Teaching Hospital
Port Harcourt, Nigeria
Not Yet Recruiting
10
Makerere University Lung Institute
Kampala, Uganda
Not Yet Recruiting
Research Team
M
Mark Loeb, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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