Actively Recruiting
Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production
Led by University of Colorado, Denver · Updated on 2026-04-29
25
Participants Needed
1
Research Sites
110 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the ability of a wearable Smart Underwear prototype device to quantify diet-induced changes in gut microbial hydrogen sulfide (H₂S) production. The core design is a single-site, 2-period, crossover feeding study with 6-day diet periods and an approximately 11-day washout period. Participants are fed each of two isocaloric diets designed to contrast gut microbial H₂S production (i.e., a high cysteine vs. low cysteine diet), in a random order.
CONDITIONS
Official Title
Smart Underwear to Measure Diet-Induced Hydrogen Sulfide Production
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Generally healthy volunteers with no major known health conditions such as diabetes, cancer, or hypertension
- Normal bowel movements, approximately one bowel movement per day
- Willingness to discuss flatus
- Age over 18 years
- Willingness to complete the entire study protocol including eating all provided food and completing all required measurements
You will not qualify if you...
- Presence of diabetes, endocrine or metabolic abnormalities, dyslipidemia, morbid obesity, severe hypertension, chronic kidney, liver, pulmonary, gastrointestinal, or cardiovascular diseases
- Use of chronic medications for the above conditions
- Food allergies interfering with study completion
- Food preferences, intolerances, or dietary requirements that interfere with diet adherence
- Planned dietary changes during the study period
- Lack of appropriate food refrigeration or preparation equipment such as an oven or microwave
- Pregnancy or planned pregnancy within the next month
- Body mass index over 35 kg/m2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
N
Noel T Mueller, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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