Actively Recruiting
SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery Trial
Led by Seoul National University Bundang Hospital · Updated on 2026-02-19
107
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to find out whether hypothyroidism caused by immune checkpoint inhibitors (ICIs) can recover after stopping the ICIs. The study also aims to identify factors that can help predict which patients will be able to stop taking thyroid hormone replacement. The main questions the study will answer are: * What percentage of patients recover normal thyroid function and can stop levothyroxine after stopping ICIs? * What clinical or laboratory factors can predict successful withdrawal of levothyroxine? Participants will: * Be adult cancer patients who developed hypothyroidism during ICI treatment and are currently taking levothyroxine * Have already stopped ICI therapy * Gradually reduce their levothyroxine dose every 3 months if their thyroid function remains normal * Stop levothyroxine if thyroid function remains normal at low doses (≤0.025 mg) * Be monitored with thyroid function tests and clinical symptoms at each visit
CONDITIONS
Official Title
SNUH Immune Checkpoint Inhibitor-induced Hypothyroidism Recovery Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 19 years or older.
- Patients with a history of treatment with immune checkpoint inhibitors (ICIs).
- Developed hypothyroidism during ICI treatment and started levothyroxine after starting ICI therapy.
- Discontinued ICI therapy before joining the study.
You will not qualify if you...
- Use of levothyroxine or antithyroid medications within 3 months before starting ICI therapy.
- History of thyroid surgery, radioactive iodine therapy, or neck radiation therapy.
- Current levothyroxine dose of 0.1 mg or higher when enrolling.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Internal Medicine, Seoul National University Bundang Hospital
Seongnam-si, South Korea
Actively Recruiting
Research Team
M
Min Joo Kim, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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