Actively Recruiting
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Led by CHU de Reims · Updated on 2026-03-13
180
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
Sponsors
C
CHU de Reims
Lead Sponsor
E
EPSM de la Marne
Collaborating Sponsor
AI-Summary
What this Trial Is About
Bipolar disorder (BD) are common psychiatric disorders often misdiagnosed, leading to delayed treatment. Even during stable phases, individuals with bipolar disorder experience residual cognitive impairments that affect their social functioning and quality of life. This study aims to explore social cognition deficits (e.g., emotional processing, theory of mind, attribution bias) and their relationship with executive functions (e.g., flexibility, inhibition, working memory) and memory in bipolar disorder and major depressive disorder, ultimately seeking to improve understanding of their functional outcomes. Social cognition and executive functions in BD are both state- and trait-related. One recent meta-analysis demonstrated impairment in social cognitive domains for manic, depressive, and euthymic bipolar disorders' patients but it remains unclear whether these social cognitive deficits in BD are due to executive functions and/or other confounding effects. Few studies have investigated the interdependency between these cognitive impairments in these two affective disorders while a better understanding of the link between executive functions and social cognition seems crucial in order to better characterize the nature of patients' deficits and thus their caring.
CONDITIONS
Official Title
Social Cognition, Memory, and Executive Functions in Bipolar Disorder and Major Depressive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients between 18 and 65 years old, men or women
- Having a diagnosis of bipolar disorder or depressive disorder
- No substantial change in treatment for 2 weeks preceding study enrollment
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
- Participants having at least one first-degree relative with bipolar disorder (parents, children, siblings)
- Participants between 18 and 65 years old, men or women
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
- Participants between 18 and 65 years old, men or women
- Being a native French speaker
- Patients enrolled in the national healthcare insurance program
- Consenting to participate to the study
You will not qualify if you...
- Presence of any alcohol use disorder or other substance use disorder in the last six months, except tobacco dependence
- Significant general medical illness, including neurological disorders or head trauma
- Uncorrected sensory impairment (visual and/or hearing)
- Diagnosis of schizophrenia or bipolar disorder or depressive disorder according to DSM-5 criteria (for first-degree relatives and healthy controls)
- Participants having one first-degree relative with bipolar disorder or depressive disorder or schizophrenia according to DSM-5 criteria (for healthy controls)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chu Reims
Reims, France, 51092
Actively Recruiting
Research Team
A
Arthur KALADJIAN
CONTACT
S
Sarah BARRIERE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
6
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