Actively Recruiting
Social Cognition Training in Individuals With Huntington's Disease
Led by Rush University Medical Center · Updated on 2025-12-10
20
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Individuals with Huntington's Disease have impaired social cognition, which is the domain of cognition that allows individuals to understand others' perspectives so that they can navigate interpersonal actions successfully (e.g., understanding someone may be sad based of their facial emotion or tone of voice and then responding in a sympathetic manner). Impaired social cognition is associated with impaired social functioning, poor psychological wellbeing and increased caregiver burden, which is known to be significant among those who care for individuals with Huntington's Disease. Computerized social cognition training has been shown to improve social cognition in individuals with schizophrenia, who, like individuals with Huntington's disease, have cognitive impairments. The investigators propose a pilot study of computerized social cognition training in individuals with Huntington's disease. This will be a feasibility study that aims to show that social cognition training in HD can be studied in preparation for a larger randomized controlled trial. The investigators hypothesize that social cognition training can improve social cognition, social functioning, and quality of life in individuals with Huntington's Disease and decrease caregiver burden among those who care for individuals with Huntington's Disease.
CONDITIONS
Official Title
Social Cognition Training in Individuals With Huntington's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Huntington's Disease based on genetic testing
- Aged between 18 and 65 years
- Native English speaker who is literate in English
- Stable psychotropic medication regimen for at least 4 weeks
- Score of "somewhat easily" on all items in the CPQ-12
- Montreal Cognitive Assessment (MOCA) score greater than 18
- Completed 12 years of schooling
- Access to a laptop or mobile device
- Willingness to attend an in-person visit 6 to 12 weeks after the first visit
- Caregiver must live with the patient
- Caregiver aged between 18 and 65 years
- Caregiver native English speaker who is literate in English
- Caregiver MOCA score greater than 26
- Caregiver willingness to attend an in-person visit within 6 to 12 weeks after the first visit
You will not qualify if you...
- Presence of any known neurological condition other than Huntington's Disease
- History of learning and/or intellectual disabilities
- Current participation in another interventional trial or completed final assessments of such a trial within the past 4 weeks
- Regularly engaging in any computerized cognitive training intervention
- Active suicidal thoughts with some intent
- Caregiver unable to provide informed consent
- Caregiver with active suicidal thoughts with some intent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Rush University Medical Center
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
T
Tyler Svymbersky
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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