Study on How Social Isolation Affects Health and Aging in People with Schizophrenia and Their Siblings Aged 40 to 70

What this Trial Is About

Researchers are studying individuals with schizophrenia and related psychotic disorders to understand how social isolation might contribute to their increased risk of early health problems and shorter lifespan. This study aims to explore the link between social isolation and physical health challenges in schizophrenia, using information from participants aged 40 to 70 years who were first studied between ages 20 to 55. The research will also investigate how the COVID-19 pandemic affected health outcomes in this group and consider differences across countries, genders, and ethnicities. The study uses an accelerated longitudinal design, combining previous research data with new follow-up assessments. It involves two groups individuals diagnosed with schizophrenia-related disorders and their unaffected first-degree relatives. Participants were initially enrolled in studies at least five years ago and will undergo comprehensive evaluations during this follow-up period. The study does not involve any treatment interventions but focuses on observing health and social factors over time. Participants will complete various assessments including health surveys, social functioning scales, and interviews about social isolation. Researchers will review medical records from earlier studies and conduct new evaluations three times daily for two weeks to track social behaviors and health status. Outcomes measured include newly diagnosed medical conditions, cholesterol and blood pressure levels, and perceived loneliness. This observational study will monitor participants health and social interactions to better understand the impact of social isolation on aging in schizophrenia.

Social Isolation and Aging in Schizophrenia