Actively Recruiting

Phase Not Applicable
Age: 18Years - 55Years
All Genders
Healthy Volunteers
NCT04565041

Social Support and Enhanced Fear Extinction

Led by University of California, Los Angeles · Updated on 2026-03-18

100

Participants Needed

1

Research Sites

230 weeks

Total Duration

On this page

Sponsors

U

University of California, Los Angeles

Lead Sponsor

N

National Institute of Mental Health (NIMH)

Collaborating Sponsor

AI-Summary

What this Trial Is About

University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to enhance the extinction of fear in healthy participants extends to those with anxiety disorders. After being recruited from the UCLA community (healthy participants, n = 50) or referred by treatment providers at the Anxiety and Depression Research Center at UCLA (anxious participants, n = 50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study, with an expected recruited 150 to reach this number. During the experiment, all participants will undergo the same procedures: undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or an image of a smiling stranger. These pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. Participants will return for a follow-up test to determine if fear extinction was successful.

CONDITIONS

Official Title

Social Support and Enhanced Fear Extinction

Who Can Participate

Age: 18Years - 55Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 55 years
  • Fluent in English
  • Healthy participants have no history of mental illness including anxiety, depression, phobia, or other mental health disorders diagnosed by a professional
  • Anxious participants have a diagnosis of social anxiety disorder; co-morbid disorders allowed include depression, other anxiety disorders, and PTSD
Not Eligible

You will not qualify if you...

  • Pregnant or planning to become pregnant during the study period
  • Healthy participants with any chronic mental illness diagnosed by a physician or psychologist or using related medication
  • Anxious participants with co-morbid bipolar disorder, psychosis, substance use disorder, neurological disorder, or obsessive-compulsive disorder
  • Current regular use of prescription medications related to mental health disorders

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

UCLA Department of Psychology

Los Angeles, California, United States, 90095-1563

Actively Recruiting

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Research Team

E

Erica Hornstein, PhD

CONTACT

N

Naomi Eisenberger, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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