Use of Buffers in Specific Contexts: Highly Trained Female Athletes, Extreme Environments and Combined Buffering Agents-A Narrative Review.
Amelia J Carr, Alannah K A McKay, Louise M Burke...
https://pubmed.ncbi.nlm.nih.gov/37878211Actively Recruiting
Phase Not Applicable
Age: 18Years - 40Years
FEMALE
Healthy Volunteers
ID06826222
The Effect of Sodium Bicarbonate Intake on Endurance Performance in Recreational Female Runners
Led by Hacettepe University · Updated on 2025-02-13
19
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the effects of sodium bicarbonate (SB) intake on endurance performance specifically in recreational female runners. This study focuses on whether consuming SB with a carbohydrate-rich meal can improve prolonged high-intensity running performance by enhancing the body's buffering system, which helps manage muscle fatigue caused by acid buildup. The study addresses a gap in research on female athletes, whose physiology may respond differently to SB compared to males, especially since only a small portion of existing studies include women. The study uses a double-blind, randomized crossover design involving 19 female recreational runners aged 18 to 40. Participants will receive two interventions: an acute dose of 0.3 g/kg sodium bicarbonate or a placebo dose of 0.03 g/kg table salt, both taken 90 minutes before exercise alongside a carbohydrate-rich meal to reduce gastrointestinal discomfort. Each participant will complete two 10 km time trials during the follicular phase of their menstrual cycle, with a 3-7 day washout period between trials. During the study, researchers will monitor gastrointestinal symptoms, 10 km run completion times, blood lactate, pH, bicarbonate levels, heart rate, and perceived exertion. Body composition and VO2max will also be assessed. Blood samples will be collected before and after exercise to analyze acid-base balance and blood gases. Hydration status will be controlled and evaluated. The primary outcome is the 10 km time-trial performance, with data analyzed using repeated measures statistical methods to compare effects of SB versus placebo.
CONDITIONS
Brief Title
Sodium Bicarbonate Intake on Endurance Performance
Who Can Participate
Age: 18Years - 40Years
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Female, aged 18 to 40 years
- Recreational runner with at least one year of regular training (minimum three days per week)
- Experience in official races of 10 km or longer
- Ability to complete a 10 km run at an average pace faster than 6 minutes per kilometer
You will not qualify if you...
- Use of medications or supplements affecting metabolism
- Acute or chronic conditions limiting physical activity (musculoskeletal, cardiovascular, or respiratory)
- Alcohol consumption or smoking habits
- Following specific diets that affect metabolism during the study (intermittent fasting, ketogenic, vegan, etc.)
- Pregnancy or breastfeeding
- Severe menstrual irregularities or amenorrhea
- Body Mass Index outside 18.5 to 30
- History of gastrointestinal disorders such as IBS or Crohn's disease
- Allergy or intolerance to sodium bicarbonate or related compounds
- History of disordered eating
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Baseline Assessments
Duration - 1 day
Participants complete baseline measurements including body composition and VO2max testing to assess fitness levels.
1 visit (in-person)
Treatment
Duration - Approximately 2 to 3 weeks including washout periods
Participants complete two intervention trials in random order: one with sodium bicarbonate and one with placebo, each followed by a 10 km time trial run to evaluate endurance performance.
4 visits (in-person) including two performance test visits and two intervention visits with standardized carbohydrate breakfasts
Follow-up
Duration - Up to 1 year
Participants are monitored after completion of interventions to analyze performance data and blood gas parameters collected during the trials.
No additional visits; data analysis and feedback provided remotely
Trial Site Locations
Total: 1 location
1
Hacettepe University
Ankara, Ankara, Turkey (Türkiye), 06800
Actively Recruiting
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Research Team
S
Selin Aktitiz, pHD Candidate
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
Frequently Asked Questions
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Published Research Related To This Trial
Effects of acute and multi-day low-dose sodium bicarbonate intake on high-intensity endurance exercise performance in male recreational cyclists.
S Aktitiz, Ş N Koşar, H H Turnagöl
https://pubmed.ncbi.nlm.nih.gov/38421429