Evaluation of Sodium Deposition in Soft Tissues of Patients with Kidney Disease and Its Association with Patient Symptomatology

What this Trial Is About

This research aims to investigate how sodium is stored abnormally in the skin, muscle, and skeleton of people with chronic kidney disease (CKD) and related conditions. Sodium storage in these tissues can cause inflammation, which may contribute to symptoms experienced by patients. The study will compare five groups: patients on hemodialysis, patients on peritoneal dialysis, adults and children with CKD stages 1-5, patients with heart failure with or without kidney problems, and healthy people matched by age and sex. Participants will have their sodium levels measured using a special MRI scan of the lower leg. They will undergo one initial study visit and may have up to two follow-up visits, with certain tests done on non-dialysis days for hemodialysis patients. Tests include questionnaires about symptoms, physical performance tests (except for children), blood pressure and heart rate checks, blood and urine samples (except for some groups), echocardiograms (except healthy controls), and the sodium MRI scan itself. During the study, participants will be monitored for up to two years. Researchers will assess sodium content in tissues, inflammation markers like CRP, symptom scores, liver and heart markers, bone markers, uremic toxins, and endotoxin levels over varying time frames. This comprehensive evaluation aims to understand how sodium buildup relates to symptoms and biochemical changes in different patient groups.

Sodium Deposition in Soft Tissues of Patients with Kidney Disease