Actively Recruiting
Sodium Deposition in Soft Tissues of Patients with Kidney Disease
Led by Chris McIntyre · Updated on 2025-02-12
400
Participants Needed
1
Research Sites
416 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Sodium (Na+) hemostasis is abnormal in CKD patients, and this element can be deposited in the skin, muscle, and skeleton - to cope with long term sodium loading. It is known that sodium stored in this non-osmotically active way, is profoundly inflammatory. Furthermore, inflammation has been associated with several uremic symptoms. The investigators will use novel Na+ MRI imaging to examine the Na+ deposition in the skin, muscle, and skeleton of five groups:1) chronic in-center hemodialysis patients, 2) chronic peritoneal dialysis patients, 3) adult and paediatric patients with CKD stage 1-5 and 4) heart failure patients with and without renal dysfunction 5) sex and age-matched healthy adult and paediatric controls. Additionally, they will investigate the association between sodium deposition in these tissues with uremic symptomatology and biochemical markers of metabolism.
CONDITIONS
Official Title
Sodium Deposition in Soft Tissues of Patients with Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than or equal to 6 years
- For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
- For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis
- For heart failure patients: with or without renal dysfunction
- For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema
- For subsequent visits, must have at least one of the following: change in dialysis prescription, change in renal replacement therapy modality, change in medication, parathyroidectomy, or intervention added to or removed from dialysis (such as exercise, cooling, or ischemic preconditioning)
You will not qualify if you...
- Pregnant, breastfeeding, or intending pregnancy
- Unable to give consent or understand written information
- Contraindication to MRI study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
LHSC Regional Renal Care Program
London, Ontario, Canada
Actively Recruiting
Research Team
C
Christopher W McIntyre, PhD, MD
CONTACT
A
Alireza Akbari, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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