Actively Recruiting
Sodium in the Skin and Atopic Dermatitis
Led by University of California, San Francisco · Updated on 2025-05-31
90
Participants Needed
2
Research Sites
172 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.
CONDITIONS
Official Title
Sodium in the Skin and Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 50 years and above
- Willing to undergo non-contrast MRI (e.g., no contraindications such as cardiac pacemakers, non-compatible intracranial vascular clips, or pregnancy)
You will not qualify if you...
- History of autoimmune disease
- Cardiac events in the last six months
- Impaired liver or kidney function (glomerular filtration rate <60 ml/min)
- Current use of medications that influence sodium excretion (e.g., thiazide diuretics, SGLT2 inhibitors, spironolactone), chemotherapy, or antibiotic treatment
- Currently receiving phototherapy or systemic medications for atopic dermatitis such as cyclosporine, methotrexate, or other broad immunosuppressive drugs
- Patients on dupilumab are excluded unless they have been on it for at least two months and still meet criteria for severe disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
San Francisco VA Medical Center
San Francisco, California, United States, 94115
Actively Recruiting
2
UCSF Mt Zion Campus
San Francisco, California, United States, 94511
Actively Recruiting
Research Team
J
Jie Zhu, MD
CONTACT
K
Katrina Abuabara, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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