Study Comparing Soft Tissue Reactions to Titanium, PEEK, Zirconia, and Lithium Disilicate Dental Implants in Adults

What this Trial Is About

Researchers are investigating how different materials used in dental implants affect the surrounding gum tissue in adults who need implants. This study focuses on understanding inflammation around dental implants made from titanium, PEEK, zirconia, and lithium disilicate. The goal is to compare these materials to determine which causes the least inflammation by measuring changes in inflammatory markers after 3 and 6 months. The study involves 40 patients missing at least four teeth in the back of the lower or upper jaw. Each patient will receive four dental implants and crowns made from each of the four materials. Researchers will evaluate the effects of each material on gum tissue by measuring markers of inflammation and clinical signs like bleeding and pocket depth around the implants at 3 and 6 months after placement. Participants will have fluid samples taken from around their implants at 3 and 6 months to analyze inflammation markers. Regular dental check-ups will measure gum health, including bleeding on probing and pocket depth. The study will monitor these outcomes to assess biocompatibility and potential risks of peri-implantitis. The total participation period includes these follow-up assessments after implant placement.

Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry