Soft Tissue Sarcoma: Instrumented Evaluation of Motor Performance and Impact of Robotic Rehabilitation, Nutrition and Quality of Life Assessment (START-RUN1)

What this Trial Is About

Researchers are studying patients with localized soft tissue sarcoma (STS), a rare group of tumors, to understand motor impairments after surgery and how personalized robotic rehabilitation might help. The study also examines the effects of surgery and related treatments on nutrition and quality of life. This non-profit, multicenter trial aims to identify motor deficits and assess recovery through detailed biomechanical assessments and patient questionnaires. Patients undergo surgery for STS and, if eligible, receive a personalized rehabilitation program focused on either the upper or lower limbs depending on tumor location. Rehabilitation combines conventional and robotic therapies, including robotic gait training and sensor-based movements for the upper limbs. Treatment sessions last 45 minutes daily, five days a week, for two months. Assessments occur at diagnosis, post-radiochemotherapy if given, one month after surgery, after rehabilitation, and up to eight months follow-up. Participants complete various evaluations including motor function tests with sensors, clinical scales for pain and disability, quality of life and nutrition questionnaires, and blood tests. Researchers track changes in physical function using the Toronto Extremity Salvage Score before and after rehabilitation. The study collects comprehensive data on patient health, tumor characteristics, and treatment outcomes over several months to better understand recovery and inform future care strategies.

Soft Tissue Sarcoma: Motor Performance, Robotic Rehabilitation, Nutrition, and Quality of Life