Actively Recruiting
Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic Retinopathies
Led by CHU de Reims · Updated on 2026-04-30
120
Participants Needed
1
Research Sites
504 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
CD160 represents a new angiogenic factor as its specific engagement by an agonist monoclonal antibody directed against human CD160 reduced angiogenesis of endothelial cells with a distinct mechanism from current angiogenic therapies that target the VEGF/VEGF-R pathway. A soluble form of CD160, sCD160, has been found to be highly expressed in the vitreous and the sera of patients with severe diabetic retinopathies, and can now be dosed with help of an ELISA test. The investigators aim to evaluate the association between ischaemic retinopathies (patients with or without) and sCD160 concentrations in the vitreous, the aqueous humour and the serum.
CONDITIONS
Official Title
Soluble Cluster of Differentiation 160 (sCD160) in Sera and Intra-ocular Fluids: Association With Ischaemic Retinopathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Over 18 years old
- Have social security affiliation
- Willing to participate in this study
You will not qualify if you...
- Received anti-VEGF therapy, corticosteroids, or immunosuppressive agents within the past 3 months
- History of vitreoretinal surgery, ocular tumor, severe eye trauma, severe intraocular or periocular infection, inflammation, or radiation
- Severe allergy to fluorescein sodium used in angiography
- History of systemic anti-VEGF treatment
- History of inflammatory or autoimmune disease
- Active extraocular inflammation or infection within 4 weeks before surgery
- C-reactive protein level greater than 10 mg/mL during surgery
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chu Reims
Reims, France, 51092
Actively Recruiting
Research Team
C
Carl ARNDT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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