Actively Recruiting
Soluble Fibre Supplementation in NAFLD
Led by McMaster University · Updated on 2024-11-12
60
Participants Needed
1
Research Sites
233 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The FIND study will look at the effect of a nutritional mixed fibre supplement, oligofructose and inulin (OF+INU), on children with non-alcoholic fatty liver disease. In this randomized, double- blind controlled trial, subjects will be given a supplement, in the form of oral pills, and will have bloodwork performed, their diets analyzed, and liver fat measured at several timepoints. Liver fat will be measured by using a specialized MRI device located at St. Joseph's Hospital. Subjects will be recruited from the Children's Exercise and Nutrition Clinic.
CONDITIONS
Official Title
Soluble Fibre Supplementation in NAFLD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children ages 8-17 years
- Diagnosed with obesity (BMI 2 standard deviations above WHO reference median)
- Enrolled in GHWM Clinic
- Clinical evidence of NAFLD with elevated ALT (>80 IU/L) and hepatic steatosis
You will not qualify if you...
- Diagnosis of type 1 or type 2 diabetes mellitus
- Contraindications to MRI such as claustrophobia, metal implants, recent tattoos, or weight over 300 lbs
- Use of other fiber supplements
- Use of medications affecting liver fat taken within the past year (e.g., glucocorticoids, anabolic steroids, tetracycline, anticonvulsants, antipsychotics, glucose-lowering drugs)
- Presence of other known liver diseases
- Allergy or hypersensitivity to OF-INU supplementation
- Self-reported alcohol intake exceeding 7 drinks/week or 3 drinks/day
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
McMaster University Medical Center
Hamilton, Ontario, Canada, L8S4K1
Actively Recruiting
Research Team
P
Paige AL Cheveldayoff, BSC
CONTACT
N
Nikhil Pai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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