Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT06605014

Somatic Dysfunction in Patients With Acute Cerebrovascular Disease

Led by University of California, Davis · Updated on 2025-09-26

120

Participants Needed

1

Research Sites

156 weeks

Total Duration

On this page

Sponsors

U

University of California, Davis

Lead Sponsor

A

American Osteopathic Association

Collaborating Sponsor

AI-Summary

What this Trial Is About

The goals of this observational study are to test the reliability of a new, standardized physical examination method to identify motion problems within joints or groups of joints among adult asymptomatic volunteers and in patients hospitalized with stroke or stroke-like episodes (e.g., transient ischemic attack, TIA). The main questions this investigation aims to answer are: * Can different, independent providers reliability quantify motion pattern problems using a systematic approach called, The Functional Pathology of the Musculoskeletal System (FPMSS) model? * Are there differences in joint(s) motion patterns among asymptomatic volunteers, patients with TIA (people with brain disease without new neurologic disability), and recent ischemic stroke (patients with new stroke-related-disability, e.g., paralysis)? * Is there an association between joint(s) motion impairment severity and stroke survivor outcomes? Participants (asymptomatic and those with stroke) will undergo a set of repeated paired, musculoskeletal physical exams by independent providers blinded to each other's assessments and patient information. Researchers will compare the severity, location, and quantity of joint(s) motion impairment between these three groups with the physical examination methodology (FPMSS). Clinical information (e.g., test results, diagnoses, brain imaging, medical history) will be collected from patients admitted for TIA and stroke. Enrolled participants with recent stroke will complete a survey three months after hospitalization to determine their self-perceived quality-of-life.

CONDITIONS

Official Title

Somatic Dysfunction in Patients With Acute Cerebrovascular Disease

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults 18 years or older
  • Admission diagnosis of ischemic stroke or transient ischemic attack (TIA); prior history of TIA without stroke may be enrolled
  • Neurologic stability or no significant deterioration (change in NIH Stroke Scale <4) for at least 24 hours in stroke subjects
  • Able to sit upright, lie on back, and when able lie on side positions with independent or minimal assistance
  • Anticipated hospital stay of 2 or more days for ischemic stroke; TIA patients with shorter stays can be enrolled
Not Eligible

You will not qualify if you...

  • Acute skeletal fracture or known dislocation; history of pathological fracture of thoracic cage, hip/pelvis/sacrum, or vertebral column
  • Prior history of intracerebral hemorrhage or ischemic stroke confirmed by imaging or clinical evaluation; chronic stroke without symptoms may be enrolled per investigator judgement
  • Use of spinal column support brace (e.g., cervical collar)
  • Planned neurosurgical intervention during hospitalization such as decompressive hemicraniectomy or hematoma evacuation
  • Current endotracheal intubation (extubated patients may be eligible)
  • History of spinal cord injury with lasting neuromuscular or sensory disability
  • Recent trauma within past 30 days
  • Known ligament, musculotendinous, or bone lesions
  • Clinical conditions interfering with movement or diagnostic testing, such as chronic pain
  • History of spinal surgery

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of California Davis Medical Center

Sacramento, California, United States, 95817

Actively Recruiting

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Research Team

A

Alan Yee, D.O.

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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