Actively Recruiting
Somatosensory Phenotyping of Patients With ADPKD Using Quantitative Sensory Testing and Questionnaires
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-11-17
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating pain in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD), a condition where many patients experience pain in the abdomen, flank, and back. This pain is often hard to manage and affects quality of life, with many patients not satisfied with current treatments. The source of pain may be unclear and common pain medications may not work well or be suitable due to kidney problems. The study aims to better understand the pain characteristics in ADPKD patients to improve pain management and explore new treatment options. The study includes two groups: patients with ADPKD aged 12 and older, and healthy volunteers matched by age, sex, and body mass index. Both groups will undergo Quantitative Sensory Testing (QST) on the dominant hand and lower back to describe their somatosensory profiles. Patients will also complete several questionnaires about pain and quality of life, while healthy volunteers will complete the BPI-SF questionnaire. Assessments will happen within three months of screening. Participants will be assessed through sensory tests and questionnaires that evaluate pain, neuropathic pain, and quality of life. Researchers will compare results between patients and healthy volunteers and study differences based on disease stage and sex. The study measures include somatosensory phenotyping and pain descriptions using specific questionnaires. The total time between screening and study visit will not exceed three months. This observational study does not involve treatment but focuses on understanding pain in ADPKD.
CONDITIONS
Brief Title
Somatosensory Phenotyping of ADPKD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with ADPKD
- Age 12 years or older
- Healthy volunteers aged 12 years or older
- Healthy volunteers matched to patients by age, sex, and body mass index
- Healthy volunteers in good general health based on medical history and vital signs
You will not qualify if you...
- Skin abnormalities such as eczema, scleroderma, psoriasis, or dermatitis on the dominant hand or lower back that may affect assessments
- Patients currently undergoing dialysis or with a kidney transplant
- Patients using tolvaptan
- Pregnant or breastfeeding females
- Participation in another study that may affect results
- Inability to avoid alcohol 24 hours before visits or consumption of 3 or more alcoholic drinks per day
- Regular use of cannabis, illicit drugs, or history of drug abuse
- Inability to avoid caffeinated beverages 24 hours before visits
- Use of drugs or treatments recently that may interfere with study results
- Any illness or condition that may interfere with safe participation or study results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 3 months after screening
Participants undergo Quantitative Sensory Testing on the dominant hand and lower back, and complete questionnaires regarding pain and quality of life to describe the somatosensory profile.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
F
Flore Van Olmen, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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