Actively Recruiting
Somatosensory Phenotyping of ADPKD
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2025-11-17
150
Participants Needed
1
Research Sites
64 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Over 60% of patients with ADPKD suffer from pain, mostly in the abdomen, flank and back, often leading to the diagnosis. It is challenging to manage and cure the pain; approximately 39% of patients are not satisfied with their pain treatment, since the pain prevents them from doing various activities, affecting their quality of life. Pain can be present before enlargement of the kidneys, the source of the pain is often unknown and common analgesics are insufficient to manage the pain or cannot be taken due to renal impairment. By further investigating and characterizing the pain phenotype of the ADPKD population, pain management might be improved and alternative therapeutic approaches might be developed. In this clinical study, pain will be assessed in patients with ADPKD using Quantitative Sensory Testing (QST) on the dominant hand and the lower back, together with four questionnaires regarding pain and quality of life. These results will be compared with the somatosensory profile of matched healthy volunteers.
CONDITIONS
Official Title
Somatosensory Phenotyping of ADPKD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with ADPKD
- 12 years of age or older
- Diagnosed with ADPKD
- Healthy volunteers 12 years or older
- Healthy volunteers in good general health based on medical history and vital signs
- Healthy volunteers matched to patients by age, sex, and BMI
You will not qualify if you...
- Skin abnormalities on dominant hand or lower back that may interfere with assessments
- Currently undergoing dialysis, had a kidney transplant, or using tolvaptan (patients)
- Pregnant or breastfeeding females
- Participation in another study that may affect results
- Unable to refrain from alcohol 24 hours before study visits or consuming 3 or more alcoholic drinks daily
- Regular use of cannabis, illicit drugs, or history of drug abuse
- Unable to refrain from caffeinated beverages 24 hours before study visits
- Use of drugs or treatments that may interfere with study results within 5 half-lives prior to enrollment
- History of illness or condition that may interfere with safe participation
- History of illness affecting normal somatosensory function (healthy volunteers)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
F
Flore Van Olmen, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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