Actively Recruiting
Somatostatin Receptor PET Imaging to Guide Radiotherapy Dose Escalation in High Risk Meningiomas.
Led by Centro di Riferimento Oncologico - Aviano · Updated on 2025-02-17
53
Participants Needed
1
Research Sites
678 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
High-risk meningiomas always require postsurgical radiation treatment. Recent evidence has shown that increased radiation therapy dose may be associated with increased intracranial control of disease. In order to better define the volume of radiation treatment, the addition of PET imaging with somatostatin receptor tracers adds additional information compared to encephalon MRI with MoC alone.The present study aims to investigate whether radiation treatment with higher doses than the standard and defined using PET imaging can be safe and at the same time effective in order to increase progression-free survival in high-risk meningiomas.
CONDITIONS
Official Title
Somatostatin Receptor PET Imaging to Guide Radiotherapy Dose Escalation in High Risk Meningiomas.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 16 years or older
- Able to give informed consent for treatment
- Diagnosis of grade III meningioma regardless of residual tumor
- Diagnosis of recurrent grade II meningioma regardless of residual tumor
- First diagnosis of grade II meningioma with residual tumor present
- Recurrence confirmed by histology or radiology
- No prior brain radiation therapy
- Performance status ECOG 0 to 2
You will not qualify if you...
- Refusal to undergo radiation treatment (no signed consent)
- Receiving other cancer treatments at the same time
- Currently pregnant
- Grade I meningiomas
- Grade II meningiomas with radical resection at first diagnosis
- Unable to undergo MRI or PET imaging
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centro di Riferimento Oncologico di Aviano (CRO)
Aviano, Pordenone, Italy, 33081
Actively Recruiting
Research Team
L
Lorenzo Vinante
CONTACT
M
Maurizio Mascarin
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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