Actively Recruiting
Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis
Led by Nanfang Hospital, Southern Medical University · Updated on 2025-07-17
300
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized, controlled, double-blinded clinical trial aims to directly compare the efficacy of Sonically Activated Irrigation (SAI) versus Passive Ultrasonic Irrigation (PUI) in the root canal treatment of teeth with chronic apical periodontitis, analyze potential influencing factors, and thereby identify a highly effective and safe root canal irrigation protocol. The ultimate goal is to provide an evidence-based rationale for optimizing irrigation technique selection and overall treatment strategies for chronic apical periodontitis.
CONDITIONS
Official Title
Sonic vs Passive Ultrasonic Irrigation for Chronic Apical Periodontitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Agree to participate in this study and provide informed consent
- Age 18-59 years at the time of enrollment
- Have at least one permanent tooth diagnosed with chronic periapical periodontitis at root development stage Nolla 10th
- Able to follow up on schedule
You will not qualify if you...
- Allergies to any medications or materials needed for the procedures
- Have non-restorable teeth, severe defects, or teeth needing extraction due to orthodontic treatment
- Teeth previously treated with root canal therapy or vital pulp therapy
- Teeth with canal calcification or root canal instrument separation
- Teeth with root fracture or vertical root fracture
- Teeth with internal or external root resorption
- Have periodontitis
- Currently undergoing orthodontic treatment
- Presence of dental phobia
- Women who are pregnant
- Taking medications affecting the central nervous system, such as tricyclic antidepressants
- Taking medications affecting immune response, such as glucocorticoids or cyclosporin
- Have had radiotherapy for tumors in head and neck area
- Taking medications affecting treatment outcome, such as bisphosphonates
- Have serious systemic diseases that may affect treatment outcome
- Participated in other clinical studies within the past several weeks
- Deemed unsuitable for study participation by investigators
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Southern Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
L
Liang Yuee
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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