Actively Recruiting
Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma
Led by Washington University School of Medicine · Updated on 2026-05-14
40
Participants Needed
1
Research Sites
345 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical study to evaluate sonobiopsy is significant because sonobiopsy will fundamentally enhance the clinician's insight into the molecular features of an intracranial lesion to tailor treatment approaches and optimize outcomes. In addition to the standard diagnostics of anatomic imaging and surgical histology, sonobiopsy has the potential to become the third pillar for brain tumor management by radically advancing the ability to easily and regularly acquire tumor genetic and molecular signatures. This enhanced capability will have a dramatic impact on patient survival and quality of life.
CONDITIONS
Official Title
Sonobiopsy for Noninvasive and Sensitive Detection of Glioblastoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed with a brain lesion consistent with glioblastoma multiforme on imaging within 28 days before enrollment
- Lesion larger than 3 cm in maximal dimension on MRI
- Lesion located in the supratentorial space within 5 cm of the cortical surface
- Lesion shows gadolinium enhancement on MRI
- Planning to undergo surgical resection of the tumor
- At least 18 years old
- Patients with recurrent glioblastoma planning surgical resection or laser ablation, with recurrence confirmed on MRI within 28 days
You will not qualify if you...
- Contraindication to MRI
- Previous cranial surgery
- Previous history of cancer or cancer treatments
- Coagulopathy within 14 days before enrollment (PT/PTT abnormal or platelets less than 100,000/mcL)
- Physical skull defect
- Ferrous material in scalp or skull
- Scalp or skin disease preventing ultrasound probe contact
- Enrolled in another clinical trial with intervention before surgery
- Known hypersensitivity to polyethylene glycol
- Unstable cardiopulmonary conditions such as recent heart attack, acute coronary syndrome, worsening heart failure, or serious arrhythmias
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
A
Albert Kim, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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