Actively Recruiting
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia
Led by UNC Lineberger Comprehensive Cancer Center · Updated on 2026-02-03
98
Participants Needed
1
Research Sites
209 weeks
Total Duration
On this page
Sponsors
U
UNC Lineberger Comprehensive Cancer Center
Lead Sponsor
N
National Institute of Dental and Craniofacial Research (NIDCR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Radiation-induced xerostomia (dry mouth) is one of the most common and severe side effects for patients receiving radiation therapy for head and neck cancer. New approaches are needed to reduce this side effect and improve patients' quality of life after treatment. This is a Phase II, single-center, double-masked, parallel-arm, randomized controlled trial. It compares MRI-guided parotid ductal sparing to the standard approach of mean parotid gland sparing, focusing on patient-reported dry mouth outcomes in individuals receiving definitive radiotherapy for oropharyngeal cancer.
CONDITIONS
Official Title
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provide written informed consent and HIPAA authorization
- Able to comply with study procedures
- Male or female aged 18 years or older
- Eastern Cooperative Oncology Group performance status 0-2
- Women of reproductive potential must use highly effective contraception
- Diagnosed with T0-4, N0-3, M0 oropharyngeal cancer planned for definitive radiotherapy with or without chemotherapy
- No contraindications for MRI
You will not qualify if you...
- Diagnosis of Sjogren's disease or baseline xerostomia
- Lesions involving the salivary glands on diagnostic imaging
- Allergy to lemon juice
- Prior lifetime radiation therapy to the head and neck
- Current pregnancy or lactation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
T
Tuvara King
CONTACT
M
Melissa Knutsen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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