Actively Recruiting
Spastic Myopathy in Adults With Cerebral Palsy
Led by Neuroloco · Updated on 2025-12-19
40
Participants Needed
1
Research Sites
393 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cerebral palsy (CP) is indeed the result of a central neurological lesion, but it also involves a lesser-known muscular condition that we refer to as spastic myopathy. This condition is likely the consequence of relative immobilization and underuse of the muscles in the affected limbs and, through a vicious cycle, it in turn plays a major role in movement difficulties. Among the muscles involved are the plantar flexors, whose extensibility decreases from the earliest years of the child's life. The BIOTN research team (UR7377; Université Paris-Est Créteil; Dr M. Pradines, Prof. J.-M. Gracies, CHU Henri Mondor, Créteil), supported by the Fondation pour la Paralysie Cérébrale, is conducting a randomized controlled study aimed, on the one hand, at characterizing in these individuals the genetic, histological, radiological, mechanical, physiological, and clinical changes in the calf muscle, and on the other hand, at exploring the reversibility of these alterations by comparing the effects of two types of rehabilitation after one year. This study will provide essential insights for the development of specific and adapted rehabilitation strategies designed to improve the living conditions of individuals with cerebral palsy.
CONDITIONS
Official Title
Spastic Myopathy in Adults With Cerebral Palsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hemiparesis or diparesis from a brain lesion occurring during the perinatal period (cerebral palsy).
- Gastrocnemius muscle extensibility XV1 less than 100° (Tardieu Scale).
- Maximum barefoot walking speed between 0.3 and 1.2 meters per second.
- Provided written informed consent to participate in the study.
You will not qualify if you...
- Botulinum toxin injections in the medial gastrocnemius within 3 months before joining the study.
- Cognitive impairment preventing participation in the rehabilitation or study.
- Under legal guardianship or conservatorship.
- Known blood clotting disorders.
- Allergic hypersensitivity.
- Presence of metallic intraocular foreign body, pacemaker, neurostimulator, cochlear implant, or any implanted electronic medical device that cannot be removed.
- Presence of metallic cardiac valve.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Maud Pradines
Créteil, Île-de-France Region, France, 94010
Actively Recruiting
Research Team
M
MAUD PRADINES, PT, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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