Actively Recruiting
Spastic Paraplegia - Centers of Excellence Research Network
Led by Boston Children's Hospital · Updated on 2026-03-18
100
Participants Needed
11
Research Sites
156 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
M
Massachusetts General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).
CONDITIONS
Official Title
Spastic Paraplegia - Centers of Excellence Research Network
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female patients of all ages with a clinical and molecular diagnosis of hereditary spastic paraplegia type 4 (SPG4, SPAST) or hereditary spastic paraplegia type 5A (SPG5A, CYP7B1).
You will not qualify if you...
- Not having a clinical and molecular diagnosis of hereditary spastic paraplegia type 4 or 5A.
- Being related to an individual with hereditary spastic paraplegia but not having the diagnosis yourself.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 11 locations
1
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
Not Yet Recruiting
2
University of Iowa Carver College of Medicine
Iowa City, Iowa, United States, 52242
Not Yet Recruiting
3
Boston Children's Hospital
Boston, Massachusetts, United States, 02215
Actively Recruiting
4
Massachusetts General Hospital
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
5
University of Michigan School of Medicine
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
6
Columbia University - Irving Medical Center
New York, New York, United States, 10032
Not Yet Recruiting
7
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229-3039
Not Yet Recruiting
8
Scottish Rite for Children
Dallas, Texas, United States, 75219
Not Yet Recruiting
9
Texas Children's Hospital
Houston, Texas, United States, 77035
Not Yet Recruiting
10
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Not Yet Recruiting
11
University of Washington School of Medicine
Seattle, Washington, United States, 98195
Not Yet Recruiting
Research Team
D
Darius Ebrahimi-Fakhari, MD, PhD.
CONTACT
N
Nicole Battaglia, BS.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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