Actively Recruiting
Spasticity in SCI Following Acute Intermittent Hypoxia
Led by Zev Rymer · Updated on 2026-05-13
10
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.
CONDITIONS
Official Title
Spasticity in SCI Following Acute Intermittent Hypoxia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Non-progressive spinal cord injury at least 6 months prior
- Injury level between C1 and C8
- ISNCSCI ASIA classification C or D
- Measurable spasticity
You will not qualify if you...
- Pre-existing hypoxic pulmonary disease
- Positive Covid-Pneumonia diagnosis within 1 year
- Uncontrolled hypertension over 140/90 mmHg
- Currently pregnant, nursing, or planning pregnancy
- Use of tracheostomy or mechanical ventilation
- Botulinum toxin injection to upper extremity in past 3 months
- Currently taking Baclofen
- Congestive heart failure
- Cardiac arrhythmias
- Uncontrolled diabetes mellitus
- Chronic obstructive pulmonary disease
- Emphysema
- Severe asthma
- Previous myocardial infarction
- Carotid or intracerebral artery stenosis
- Orthopedic injuries or surgeries affecting upper extremity use
- History of epilepsy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shirley Ryan AbilityLab
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
W
William Z Rymer, MD, PhD
CONTACT
A
Alexander Barry, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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