Actively Recruiting
Spatiotemporal Stereotactic Body Radiation Therapy for the Treatment of Patients With Polymetastatic Solid Tumors
Led by City of Hope Medical Center · Updated on 2025-06-17
20
Participants Needed
1
Research Sites
232 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial evaluates the safety and effectiveness of spatiotemporal stereotactic body radiation therapy (ST-SBRT) in treating patients with solid tumors that have spread to other parts of the body (polymetastatic). SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. ST-SBRT is designed to deliver radiation directly to the core of the tumor, while keeping the radiation exposure of the area around the tumor at minimal dosage.
CONDITIONS
Official Title
Spatiotemporal Stereotactic Body Radiation Therapy for the Treatment of Patients With Polymetastatic Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provided informed consent and assent if required
- Age 18 years or older
- Karnofsky performance status greater than 60
- Polymetastatic disease with more than 5 lesions and at least one lesion larger than 2.0 cm
- Limited treatment options and ineligible for or progressing under standard systemic therapy
- Intervention can be administered without exceeding dose constraints
- Brain metastases treated prior to enrollment with stable MRI findings 3 months after treatment
- Spinal cord metastases allowed if treatment completed
- Prior radiotherapy allowed if dose constraints are met
- Life expectancy of 3 months or more
- Off systemic therapy at least one month before and after study intervention
You will not qualify if you...
- Investigator judgment that patient is unsuitable or unlikely to comply with study procedures
- Not eligible for SBRT after radiation oncologist review
- Serious medical conditions preventing radiotherapy
- Unable to undergo CT scan
- Pregnant or breastfeeding women; females of childbearing potential must have negative pregnancy test within 72 hours before therapy
- On active systemic therapy
- May not comply with study procedures or feasibility requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here