Actively Recruiting
Spatiotemporal tSCS in Spinal Cord Injury
Led by Washington University School of Medicine · Updated on 2026-02-12
48
Participants Needed
1
Research Sites
240 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in muscle recruitment compared to invasive approaches limits the type of rehabilitation exercises that can be practiced. This project studies how spatial, frequency, and amplitude control of stimulation can be used to selectively target different neural pathways and muscle groups.
CONDITIONS
Official Title
Spatiotemporal tSCS in Spinal Cord Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 16 and 65 years
- Have a spinal cord injury at neurological level C3 to T12 that occurred at least 1 year before enrollment
- Classified as ASIA Impairment Scale C or D
- Able to voluntarily contract at least two leg muscles with visible or palpable contraction
- Prescription medication for spasticity has been stable for at least 2 weeks
- Able to provide informed consent
- Able to follow multiple instructions and communicate pain or discomfort
You will not qualify if you...
- Progressive spinal lesions including degenerative spinal cord disorders
- Pregnant, planning pregnancy, or currently breastfeeding
- History of cardiopulmonary disease or cardiac symptoms
- Have implanted stimulators such as baclofen pump, spinal stimulator, cardiac defibrillator, or pacemaker
- Orthopedic conditions that interfere with leg exercise participation
- History of severe, unstable, or uncontrolled autonomic dysreflexia
- Unstable or significant medical conditions affecting exercise or evaluations, including severe neuropathic pain, depression, mood, or cognitive disorders
- Spasms that limit participation in leg exercise
- Skin breakdown in areas where electrodes would be placed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University, St. Louis
St Louis, Missouri, United States, 63130
Actively Recruiting
Research Team
I
Ismael Seáñez, PhD
CONTACT
C
Carolyn Atkinson, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here