Actively Recruiting
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Led by University Hospital Freiburg · Updated on 2025-03-25
1500
Participants Needed
18
Research Sites
291 weeks
Total Duration
On this page
Sponsors
U
University Hospital Freiburg
Lead Sponsor
C
Charite University, Berlin, Germany
Collaborating Sponsor
AI-Summary
What this Trial Is About
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
CONDITIONS
Official Title
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Definitive (chemo-)radiotherapy for locally advanced head-and-neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, hypopharynx, or larynx
- Primary treatment started since 2005
- Age 65 years or older at the time of (chemo-)radiotherapy
You will not qualify if you...
- Receiving adjuvant (chemo-)radiotherapy
- History of previous head-and-neck cancers or prior radiotherapy in the head-and-neck region
- Presence of distant metastases at the start of (chemo-)radiotherapy (cM1)
- HNSCC of the nasopharynx, salivary glands, skin, or unknown primary site
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 18 locations
1
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Baltimore, Maryland, United States, 21287
Completed
2
Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10017
Completed
3
Department of Radiation Oncology, Case Western Reserve University
Cleveland, Ohio, United States, 10900
Completed
4
Division of Radiation Oncology, The Ohio State University Wexner
Columbus, Ohio, United States, 43201
Completed
5
Radiation Oncology Department, German Oncology Center
Limassol, Cyprus
Completed
6
Brno University Hospital
Brno, Czechia
Completed
7
Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin
Berlin, Germany
Completed
8
Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg
Erlangen, Germany
Completed
9
Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main
Frankfurt, Germany
Completed
10
University of Giessen
Giessen, Germany
Completed
11
Martin-Luther-Universität Halle-Wittenberg
Halle, Germany
Completed
12
Jena University Hospital
Jena, Germany
Actively Recruiting
13
Department of Radiation Oncology, University Hospital Schleswig-Holstein
Kiel, Germany
Completed
14
Department of Radiation Oncology, University Medical Center Leipzig
Leipzig, Germany
Completed
15
Department of Radiation Oncology, University Medical Center Mainz
Mainz, Germany
Completed
16
Department of Radiation Oncology, University Hospital, LMU Munich
Munich, Germany
Completed
17
Department of Radiation Oncology, University Hospital Würzburg
Würzburg, Germany
Completed
18
Department of Radiation Oncology, University Hospital Zurich (USZ), University of Zurich (UZH)
Zurich, Switzerland
Completed
Research Team
A
Alexander Rühle, MD, MHBA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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