Collection of Blood, Bone Marrow, Tumor, or Tissue Samples From Patients With HIV Infection, KSHV Infection, Viral-Related Pre-Malignant Lesions, and/or Cancer

What this Trial Is About

Researchers are investigating the collection and study of various biological samples from adults with HIV infection, Kaposi's sarcoma-associated herpesvirus (KSHV) infection, other oncogenic viruses, or related cancers. This observational study aims to acquire blood, bone marrow, tumor, and other tissue samples to support scientific advances in understanding these infections and associated malignancies. The study is sponsored by the National Cancer Institute (NCI) and includes participants aged 18 years or older who have risk factors or infections related to HIV, KSHV, or similar viruses. Participants provide samples such as blood at initial and follow-up visits. Other fluids and excretions like urine, saliva, semen, and stool may also be collected. When accessible with minimal risk, tumor samples can be taken through procedures like fine needle aspirate, fluid removal, skin punch biopsy, or excisional biopsy. Detailed risks of biopsy procedures are explained and consented separately. Samples are analyzed in specialized laboratories affiliated with NCI or collaborating investigators. During the study, participants undergo sample collection and may provide various biological fluids and tissues over time. Researchers monitor the acquisition of these samples to support ongoing research efforts. The main outcome measure focuses on successfully obtaining serum, circulating cells, bone marrow, and tumor or normal tissue samples. Participation is observational with no treatment interventions, and the study accommodates up to 999 participants. There is no specified study end date, and involvement duration depends on follow-up visits for sample collection.

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer