Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
NCT03657524

Speckle Tracking Echocardiography for the Prediction of Weaning Failure

Led by Assistance Publique Hopitaux De Marseille · Updated on 2026-02-12

110

Participants Needed

1

Research Sites

365 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate. Recent studies suggest that isolated sonographic assessment of the respiratory and cardiac function (ie diastolic function and filling pressure), in mechanically ventilated patients may assist in identifying patients at risk of weaning failure. Recently, the association of conventional echocardiography and lung ultrasound showed promising results for the prediction of post extubation distress. Speckle Tracking is an emerging tool in intensive care medicine that has never been investiguated for the prediction of weaning failure. It could early detects diastolic dysfunction and and elevated filling pressure. Of more, speckle tracking is known to be less operator dependant. The main objective of our study is to evaluate the diagnosis accuracy of speckle tracking echocardiography performed during a weaning trial to predict weaning failure. The secondary objectives are to assess the diagnosis accuracy of combined heart and lung ultrasound to predict weaning failure.

CONDITIONS

Official Title

Speckle Tracking Echocardiography for the Prediction of Weaning Failure

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial.
Not Eligible

You will not qualify if you...

  • Under 18 years old.
  • Pregnancy.
  • Non sinusal cardiac rhythm.
  • Neuro Myopathy.
  • Tracheotomy.
  • Lack of echogenicity to perform at least a four chamber apical view.

AI-Screening

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Trial Site Locations

Total: 1 location

1

Assistance Publique Hôpitaux de Marseille

Marseille, France, 13015

Actively Recruiting

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Research Team

L

Laurent ZIELESKIEWICZ

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

OTHER

Number of Arms

2

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