Actively Recruiting
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Led by Canadian Cancer Trials Group · Updated on 2026-05-12
510
Participants Needed
36
Research Sites
446 weeks
Total Duration
On this page
Sponsors
C
Canadian Cancer Trials Group
Lead Sponsor
A
Alliance for Clinical Trials in Oncology
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?
CONDITIONS
Official Title
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with confirmed lateralized oropharyngeal cancer not crossing midline
- HPV positive or negative by p16 immunohistochemistry
- Clinical stage T1-3 M0 with possible ipsilateral lymph node involvement up to 6 cm
- Recent CT or MRI of the neck, PET-CT, and chest CT within 8 weeks before registration
- Planned radiotherapy or chemoradiotherapy with bilateral neck treatment
- Known intent regarding concurrent chemotherapy at randomization
- ECOG performance status of 0, 1, or 2
- Willing to complete quality of life questionnaires in available languages
- Provided informed consent prior to registration
- Accessible for treatment and follow-up
- Start definitive radiotherapy within 28 days (+14 days) of randomization
- Acceptable injection procedure settings for lymphatic mapping
- Use of highly effective contraception if of childbearing potential
- Prior or concurrent cancers allowed if not interfering with study
- Consent to provide tumor tissue samples for marker assays
You will not qualify if you...
- T1-T2 cancers isolated to tonsil fossa without involved lymph nodes or with a single small ipsilateral node less than 3 cm without extranodal extension
- Prior diagnostic tonsillectomy or lingual tonsillectomy with no residual disease for tonsil or tongue base cancer
- Previous head and neck cancer or multiple synchronous primary cancers
- Previous induction or neoadjuvant chemotherapy
- Previous head and neck radiation therapy or extensive neck dissection involving at least 3 levels on either side
- Allergy to radiotracers
- Severe active co-morbidities including recent hospitalization for lung disease, unstable angina, congestive heart failure, or recent heart attack
- Diseases preventing radiotherapy such as scleroderma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 36 locations
1
City of Hope Corona
Corona, California, United States, 92882
Actively Recruiting
2
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Actively Recruiting
3
City of Hope at Irvine Lennar
Irvine, California, United States, 92618
Suspended
4
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States, 33146
Actively Recruiting
5
Baptist MD Anderson Cancer Center
Jacksonville, Florida, United States, 32207
Active, Not Recruiting
6
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
7
Moffitt Cancer Center-International Plaza
Tampa, Florida, United States, 33607
Actively Recruiting
8
Moffitt Cancer Center - McKinley Campus
Tampa, Florida, United States, 33612
Actively Recruiting
9
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
10
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
11
Northwestern University
Chicago, Illinois, United States, 60611
Active, Not Recruiting
12
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Active, Not Recruiting
13
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, United States, 40202
Suspended
14
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
15
University of Michigan - Brighton Center for Specialty Care
Brighton, Michigan, United States, 48116
Actively Recruiting
16
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
17
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, United States, 65212
Actively Recruiting
18
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
19
Providence Portland Medical Center
Portland, Oregon, United States, 97213
Actively Recruiting
20
MD Anderson in The Woodlands
Conroe, Texas, United States, 77384
Actively Recruiting
21
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
22
MD Anderson West Houston
Houston, Texas, United States, 77079
Actively Recruiting
23
MD Anderson League City
League City, Texas, United States, 77573
Actively Recruiting
24
MD Anderson in Sugar Land
Sugar Land, Texas, United States, 77478
Actively Recruiting
25
University of Vermont Medical Center
Burlington, Vermont, United States, 05401
Actively Recruiting
26
University of Vermont and State Agricultural College
Burlington, Vermont, United States, 05405
Actively Recruiting
27
BCCA-Vancouver Cancer Centre
Vancouver, British Columbia, Canada, V5Z 4E6
Actively Recruiting
28
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Actively Recruiting
29
Health Sciences North
Greater Sudbury, Ontario, Canada, P3E 5J1
Actively Recruiting
30
Saint Joseph's Healthcare Charlton Campus
Hamilton, Ontario, Canada, L8N 4A6
Suspended
31
Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8V 5C2
Actively Recruiting
32
Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Suspended
33
University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
34
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
35
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Suspended
36
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
Research Team
W
Wendy Parulekar
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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