Actively Recruiting
SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-03-30
80
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will study SPECT imaging of radiopharmaceutical therapies given as standard of care or as part of other compatible research protocols. The goal is to validate the quantitative SPECT image reconstruction methods developed in this proposal, and to investigate the relation between dosimetry calculated from SPECT images and the outcomes. Patients will be recruited for SPECT/CT imaging during treatment. This is an observational study no additional new drugs or activities will be administrated. The investigators will perform SPECT imaging on a total of 80 patients (\~20 each from year 2 to year 5). Each participant will be imaged 3 times after the first and last cycles of planned radiopharmaceutical therapy.
CONDITIONS
Official Title
SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with advanced prostate cancer planning treatment with Radium-223
- Patients with advanced cancer undergoing treatment with 177Lu-DOTATATE or 177Lu-PSMA-617
- Eligible patients may receive these treatments as standard care or as part of another research protocol
- Age over 18 years
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
- Histologic confirmation of malignancy
You will not qualify if you...
- Participation in another research protocol incompatible with this imaging protocol or its schedule
- Inability to tolerate SPECT scan time, scan frequency, or required positioning
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Trial Site Locations
Total: 1 location
1
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
A
Ana Kiess
CONTACT
R
Ryan Manuel
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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