Studying How the Brain Learns and Remembers Speech Movements Using Brain Stimulation and Imaging in Adults 18 to 40

What this Trial Is About

This research investigates how speech motor learning and retention are linked to changes not only in motor areas of the brain but also in auditory and somatosensory regions. The study aims to test a new model of speech motor learning by examining brain plasticity during learning and retention phases. Participants will engage in speech learning tasks under different conditions. In Aim 1, continuous theta-burst stimulation cTBS is applied to specific brain areas after learning to assess its effect on memory retention, measured 24 hours later. Aim 2 involves measuring motor cortex excitability using single-pulse transcranial magnetic stimulation TMS during learning with altered auditory feedback. Aim 3 combines resting-state functional MRI fMRI scans with speech learning tasks to study brain connectivity related to learning. Throughout the study, participants speech motor learning performance is measured immediately after learning sessions and again 24 hours later to assess retention. Various brain imaging and stimulation techniques are used to monitor brain activity and plasticity. The study includes behavioral tests, brain scans, and stimulation sessions, with all assessments designed to better understand speech motor learning and its neural basis.

Speech Motor Learning and Retention (Master Protocol)