Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting to Restore Fertility in Males

What this Trial Is About

This research aims to evaluate the safety and feasibility of spermatogonial stem cell transplantation and testicular tissue grafting to restore fertility in male participants who have previously frozen testicular tissue before undergoing treatments that risk infertility. The study focuses on adult men affected by infertility due to loss or damage of spermatogonial stem cells caused by diseases or medical therapies such as chemotherapy or radiation. It addresses a critical need for patients who could not preserve semen samples prior to treatment, especially prepubertal males. Participants will receive one of two experimental procedures: autologous transplantation of testicular cells, including spermatogonial stem cells, using ultrasound-guided rete testis injection, or autologous grafting of intact testicular tissue pieces under the skin of the scrotum. Both methods use the participant's own previously cryopreserved testicular tissue or cells. These procedures are designed to stimulate sperm production and are monitored for safety and effectiveness. During the study, participants will be assessed for the return of sperm production between 3 months and 1 year after treatment. Researchers will also monitor for any surgical complications within 3 months and track cancer recurrence over a 5-year period. Participant involvement includes medical evaluations, clearance from hematologists or oncologists, and follow-up visits to measure outcomes related to fertility restoration and safety. The total duration and follow-up extend up to 5 years, ensuring thorough monitoring of long-term effects.

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting