Actively Recruiting

Phase Not Applicable
MALE
NCT04452305

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Led by University of Pittsburgh · Updated on 2026-04-22

10

Participants Needed

1

Research Sites

342 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

CONDITIONS

Official Title

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Who Can Participate

MALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Male participant at least in Tanner stage 3
  • Previously cryopreserved and stored testicular tissue or cells available for transplantation
  • Healthy enough to undergo anesthesia
  • Written clearance from hematologist or oncologist confirming completion of primary treatment and readiness for transplant
Not Eligible

You will not qualify if you...

  • High risk for surgical complications
  • History of leukemia, lymphoma, testicular cancer, or cancer involving testicles at tissue collection
  • Psychological, psychiatric, or other conditions preventing fully informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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3
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Trial Site Locations

Total: 1 location

1

Magee-Womens Hospital

Pittsburgh, Pennsylvania, United States, 15213

Actively Recruiting

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Research Team

J

Jennifer L Anglin

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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